Antiretroviral adherence interventions: translating research findings to the real world clinic.
Antiretroviral adherence interventions: translating research findings to the real world clinic.
复制标题
DOI：
10.1007/s11904-009-0037-5
复制
发表时间：
2010-02
影响因子：
4.6
通讯作者：
Nelson, Kimberly
中科院分区：
文献类型：
--
作者：
Simoni, Jane M;Amico, K Rivet;Smith, Laramie;Nelson, Kimberly
有效的抗逆转录病毒联合疗法（ART）治疗HIV感染的成功主要是由于未能长期保持最佳水平的依从性。最近的综述表明，促进ART依从性的行为干预可能具有显著的效果，但这些效果往往很小，并且随着时间的推移而减少;生物标志物的持续改善尤其难以实现。在这篇文章中，我们更新了当前的评论，特别关注自2007年9月以来发表的13项评估行为干预以促进ART依从性的研究。我们描述了一系列的干预策略，并定性总结其疗效的结果。总之，我们认为影响，并提供策略，以提高坚持在临床为基础的艾滋病毒治疗开始之前，在启动，并在整个治疗过程中。
The success of potent combination antiretroviral therapy (ART) for HIV infection is compromised primarily by failure to maintain optimal levels of adherence over the long term. Recent reviews suggest behavioral interventions to promote ART adherence can have significant effects, but these tend to be small and to diminish over time; sustained improvements in biomarkers are particularly elusive. In this article, we update current reviews, focusing specifically on the 13 studies evaluating behavioral interventions to promote ART adherence published since September 2007. We describe the range of intervention strategies employed and qualitatively summarize findings of their efficacy. In conclusion, we consider implications and offer strategies for enhancing adherence in clinic-based HIV care prior to ART initiation, at initiation, and over the course of treatment.