Controlled Myocardial Injury Produced by a Hypothermal Method
Controlled Myocardial Injury Produced by a Hypothermal Method
复制标题
低温法产生的可控心肌损伤
DOI：
10.1161/01.cir.3.2.239
复制
发表时间：
1951
期刊：
影响因子：
37.8
通讯作者：
G. Hass
中科院分区：
文献类型：
--
作者：
C. B. Taylor;Charles Davis;G. Vawter;G. Hass
在回顾了用于心肌坏死或失活的实验方法之后，描述了一种采用低温的新方法。肌细胞完全坏死的病变可以控制大小，并可以选择性地累及四个心腔和室间隔中的任何一个。这有助于从受损肌肉的数量和位置方面研究慢性心肌功能不全。此外，也可能通过产生小的室间隔病变来产生传导障碍。对心室病变的大小和位置进行精确的心电图分析是不可能的。
Following a review of experimental methods used for the production of necrosis or inactivation of the myocardium, a new method employing low temperatures is described. Lesions, with complete necrosis of muscle cells, can be controlled as to size and can be selectively placed to involve any of the four cardiac chambers and the interventricular septum. This facilitates attempts to study chronic myocardial insufficiency in terms of quantity and location of damaged muscle. Also, it has been possible to produce disturbances in conduction by production of small interventricular septal lesions. Refined electrocardiographic analysis of the magnitude and location of ventricular lesions has not been possible.