The acute effects of 1,25-dihydroxycholecalciferol on serum immunoreactive parathyroid hormone in the dog.
The acute effects of 1,25-dihydroxycholecalciferol on serum immunoreactive parathyroid hormone in the dog.
复制标题
1,25-二羟基胆钙化醇对狗血清免疫反应性甲状旁腺激素的急性影响。
作者：
S. Oldham;R. Smith;D. Hartenbower;H. Henry;A. Norman;J. Coburn
有大量证据表明甲状旁腺可能是维生素 D 代谢物的目标。为了研究 1,25-二羟基胆钙化醇 [1,25(OH)2D3] 对甲状旁腺激素 (PTH) 分泌的影响，在 5 只正常幼犬和 9 只缺乏维生素 D 的幼犬中单次静脉注射 1 μg (2.4 nmol) 1,25(OH)2D3 后 12 小时内测量免疫反应性 PTH (IPTH)、钙和磷酸盐的血清浓度。在维生素 D 缺乏的动物中，平均血清钙在 8 小时内显着增加，并在 12 小时时比基础值高出约 1 mg/dl。 1,25(OH)2D3 后血清磷酸盐浓度没有显着变化。在大多数（但不是全部）缺乏维生素 D 的幼犬中注射 1,25(OH)2D3 后，血清 IPTH 浓度会出现急性、短暂的升高。然而，该组平均血清 IPTH 浓度的增加并不具有统计学意义。 12 小时时，平均 IPTH 浓度较基础值显着下降...
There is considerable evidence which suggests that the parathyroid gland may be a target for vitamin D metabolites. To investigate the effects of 1,25-dihydroxycholecalciferol [1,25(OH)2D3] on parathyroid hormone (PTH) secretion, the serum concentrations of immunoreactive PTH (IPTH), calcium, and phosphate were measured over a 12-h period after the single iv injection of 1 μg (2.4 nmol) 1,25(OH)2D3 in five normal and nine vitamin D-deficient puppies. In the vitamin Ddeficient animals, the mean serum calcium increased significantly by 8 h, and at 12 h was approximately 1 mg/dl above the basal value. Serum phosphate concentrations showed no significant change after 1,25(OH)2D3. An acute, transient increase in serum IPTH concentration followed the injection of 1,25(OH)2D3 in most but not all of the vitamin D-deficient puppies. However, the increase was not statistically significant in the mean serum IPTH concentration for the group. At 12 h, the mean IPTH concenration had decreased significantly from the bas...