Topographic Relationship between Telangiectasia and Cone Mosaic Disruption in Macular Telangiectasia Type 2.
Topographic Relationship between Telangiectasia and Cone Mosaic Disruption in Macular Telangiectasia Type 2.
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DOI：
10.3390/jcm9103149
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发表时间：
2020-09-29
影响因子：
3.9
通讯作者：
Fawzi AA
中科院分区：
文献类型：
--
作者：
Zandi R;Song J;Micevych PS;Fawzi AA
在这项横断面观察性研究中，我们研究了诊断为早期2型黄斑毛细血管扩张症（MacTel）的患者中感光层破坏与毛细血管扩张之间的关系。对17例31眼MacTel患者行自适应光学扫描激光检眼镜（AOSLO）和光学相干断层扫描血管造影（OCTA）检查。共聚焦AOSLO用于可视化非波导外节的暗区，我们称之为“光感受器病变”。与共焦AOSLO结合使用深部毛细血管丛（DCP）的正面OCTA图像，以评估毛细血管扩张区与感光细胞病变之间的地形关系。在早期MacTel（基于OCT的0-2期）的7只眼睛中，我们确定了10个感光细胞病变，所有这些病变均位于OCTA上包含DCP毛细血管扩张的视神经旁象限内。其中7处病变对应于光谱域OCT（SD-OCT）上的完整椭圆体区，其中3处也对应于完整的指状交错区。这项工作证明了AOSLO感光细胞病变和DCP毛细血管扩张之间的地形关系，它也表明，这些病变与正常的SD-OCT外观可能代表的感光细胞功能障碍的风险领域。因此，共焦AOSLO可能具有有意义的作用，在检测早期感光异常的眼睛与MacTel。
In this cross-sectional observational study, we investigated the relationship between photoreceptor layer disruption and telangiectasia in patients diagnosed with early stage macular telangiectasia type 2 (MacTel). A total of 31 eyes (17 patients) with MacTel were imaged with adaptive optics scanning laser ophthalmoscopy (AOSLO) and optical coherence tomography angiography (OCTA). Confocal AOSLO was used to visualize dark regions of nonwaveguiding outer segments, which we refer to as “photoreceptor lesions”. En-face OCTA images of the deep capillary plexus (DCP) were used in conjunction with confocal AOSLO to evaluate the topographic relationship between areas of capillary telangiectasias and photoreceptor lesions. Among seven eyes with early stage MacTel (stage 0–2 based on OCT), we identified ten photoreceptor lesions, all of which were located within parafoveal quadrants containing DCP telangiectasia on OCTA. Seven of the lesions corresponded to the intact ellipsoid zone on spectral-domain OCT (SD-OCT), and three of these also corresponded to the intact interdigitation zone. This work demonstrates a topographic relationship between AOSLO photoreceptor lesions and DCP telangiectasias, and it also suggests that these lesions with normal SD-OCT appearance may represent areas of photoreceptors at risk for dysfunction. Thus, confocal AOSLO may have a meaningful role in detecting early photoreceptor abnormalities in eyes with MacTel.
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影响因子：
3.8
作者：
Jia Y;Tan O;Tokayer J;Potsaid B;Wang Y;Liu JJ;Kraus MF;Subhash H;Fujimoto JG;Hornegger J;Huang D
通讯作者：
Huang D
影响因子：
13.7
作者：
Chew, Emily Y.;Clemons, Traci E.;Friedlander, Martin
通讯作者：
Friedlander, Martin
DOI：
10.1523/jneurosci.2841-12.2012
发表时间：
2012-11-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Shen W;Fruttiger M;Zhu L;Chung SH;Barnett NL;Kirk JK;Lee S;Coorey NJ;Killingsworth M;Sherman LS;Gillies MC
通讯作者：
Gillies MC
影响因子：
3
作者：
Cooper RF;Sulai YN;Dubis AM;Chui TY;Rosen RB;Michaelides M;Dubra A;Carroll J
通讯作者：
Carroll J
影响因子：
4.4
作者：
Ooto, Sotaro;Hangai, Masanori;Yoshimura, Nagahisa
通讯作者：
Yoshimura, Nagahisa