Prognostic Impact of Preoperative Albumin-to-Globulin Ratio in Patients with Colon Cancer Undergoing Surgery with Curative Intent
Prognostic Impact of Preoperative Albumin-to-Globulin Ratio in Patients with Colon Cancer Undergoing Surgery with Curative Intent
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DOI：
10.21873/anticanres.11452
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发表时间：
2017-03-01
影响因子：
2
通讯作者：
Kusunoki, Masato
中科院分区：
文献类型：
--
作者：
Fujikawa, Hiroyuki;Toiyama, Yuji;Kusunoki, Masato
目的：为了确定结肠癌（CC）患者接受根治性手术后预后不良的预测因素，我们研究了白蛋白与球蛋白比值（AGR）与临床病理结果（如总生存期（OS）和无病生存期（DFS））之间的关系。患者和方法：我们对248例I-III期CC患者的临床病理结果进行了回顾性研究，包括术前实验室数据。结果：低AGR患者的DFS和OS均短于高AGR患者。多变量分析表明，低AGR是与CC患者复发和预后不良独立相关的独立变量，这些患者接受了根治性手术，无论淋巴结转移如何。结论：术前AGR是接受根治性手术的CC患者复发和预后不良的独立预测因素。AGR表明，这些患者可能受益于强化辅助治疗。
Aim: To identify predictors of poor prognosis of patients with colon cancer (CC) who underwent surgery with curative intent, we investigated the association between the albumin to globulin ratio (AGR) with clinicopathological findings such as overall (OS) and disease-free (DFS) survival. Patients and Methods: We conducted a retrospective study of clinicopathological findings, including preoperative laboratory data, for 248 patients with stage I-III CC. Results: Patients with low AGR had shorter DFS and OS compared to those with high AGR. Multivariate analyses identified low AGR as an independent variable independently associated with recurrence and poor prognosis of patients with CC who underwent surgery with curative intent regardless of lymphnode metastasis. Conclusion: The preoperative AGR was an independent predictor of recurrence and poor prognosis of patients with CC who underwent surgery with curative intent. The AGR indicates that these patients may benefit from intensive adjuvant therapy.