ULTRASTRUCTURE OF GASTRIC MUCOSA IN NORMAL AND HYPOPHYSECTOMIZED RATS
ULTRASTRUCTURE OF GASTRIC MUCOSA IN NORMAL AND HYPOPHYSECTOMIZED RATS
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DOI：
10.1002/aja.1001180105
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发表时间：
1966-01-01
影响因子：
--
通讯作者：
CORPRON, RE
中科院分区：
文献类型：
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作者：
CORPRON, RE
本研究的目的是用电镜观察大鼠胃底腺颈部和峡部的上皮细胞类型，以及垂体切除术对胃底腺的影响。大鼠胃底腺颈部可区分以下细胞类型：未分化细胞、未成熟表面细胞、颈粘液细胞和颈壁细胞。在正常腺体中，这些细胞类型彼此相似，具有低密度的低密度细胞质和核质、发育不良的内质网、很少的线粒体和大量的游离核糖体。粘液颈和未成熟表面细胞之间最重要的结构差异是分泌颗粒的对比密度。这两种细胞类型与未分化细胞的区别主要在于其特征性分泌颗粒的存在。颈壁细胞似乎是未成熟表面细胞和成熟壁细胞之间的发育形式。在这些细胞中没有观察到垂体切除术导致的变化。垂体切除术引起主细胞显着的退化变化，主要涉及与蛋白质合成最直接相关的细胞器，即麦质和高尔基体。这些效应与嗜碱性粒细胞和分泌颗粒的丧失以及细胞大小和分泌胃蛋白酶原的能力的减少有关，如前所述。相比之下，与电解质运输有关的壁细胞受到的影响要小得多。
The objectives of this study were to observe with the electron microscope the epithelial cell types found in the neck and isthmus of the gastric fundic gland of the rat, and the effects of hypophysectomy on the gland. The following cell types were distinguished in the neck of the fundic gland of the rat: nondifferentiated cell, immature surface cell, mucous neck cell, and neck parietal cell. In the normal gland, these cell types resembled each other in the possession of a ground cytoplasm and nucleoplasm of low density, a poorly developed endo-plasmic reticulum, few mitochondria and numerous free ribosomes. The most important structural difference between mucous neck and immature surface cells was the contrasting density of the secretory granules; both cell types differed from the nondifferentiated cell primarily in the presence of their characteristic secretory granules. The neck parietal cell appeared to be a developmental form between the immature surface cell and the mature parietal cell. No changes were observed in these cells to result from hypophysectomy. Hypophysectomy caused marked involutional changes in the chief cell which involved mainly the organelles most directly concerned with protein synthesis, i.e., the ergastoplasm and Golgi apparatus. These effects were correlated with the loss of basophilia and secretory granules and with the reduction in cell size and capacity to secrete pepsinogen which were described previously. In contrast, the parietal cell, which is concerned with electrolyte transport, was affected much less.