Cytokine Polymorphisms in the Pathophysiology of Mood Disorders
Cytokine Polymorphisms in the Pathophysiology of Mood Disorders
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DOI：
10.1017/s1092852900020393
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发表时间：
2009-08-01
期刊：
影响因子：
3.3
通讯作者：
Altamura, A. Carlo
中科院分区：
文献类型：
--
作者：
Clerici, Mario;Arosio, Beatrice;Altamura, A. Carlo
简介：越来越多的数据表明，免疫系统（包括细胞因子网络）的失调与情绪障碍的病因和病理生理学有关。编码细胞因子的基因具有高度多态性，并且已经描述了与细胞因子产生的增加或减少相关的单核苷酸多态性。本研究的目的是确定与重度抑郁症 (MDD) 和双相情感障碍相关的遗传免疫学情况。 方法：84 名患有双相情感障碍 1 型、双相情感障碍 11 型或 MDD 的意大利门诊患者和 363 名健康对照者被纳入该研究。我们通过聚合酶链式反应序列特异性引物技术分析了 -308 (G/A) 肿瘤坏死因子-α (TNF-α)、+874 (T/A) 干扰素-γ (IFN-gamma)、-174 (G/C) 白细胞介素 (IL)-6 和 -1082 (G/A) IL-10 启动子多态性的等位基因和基因型分布。分析三组患者中 TNF-α、IFN-γ 和 IL-10 多态性的等位基因分布。特别是，11 名双相情感障碍患者的特点是缺乏 TNF-α 的腺嘌呤 (A) 高产等位基因（P
Introduction: An increasing amount of data suggests that dysregulation of the immune system, including the cytokine network, is associated with the etiology and pathophysiology of mood disorders. Genes encoding cytokines are highly polymorphic and single nucleotide polymorphisms, associated with increased or reduced cytokine production, have been described. The aim of this study was to define the genetic immunologic scenario associated with major depressive disorder (MDD) and bipolar disorder.Methods: Eighty-four Italian outpatients affected by bipolar disorder type 1, bipolar disorder type 11, or MDD, and 363 healthy controls were enrolled into the study. We analyzed allele and genotype distribution of -308 (G/A) tumor necrosis factor-alpha (TNF-alpha), +874 (T/A) interferon-gamma (IFN-gamma), -174 (G/C) interleukin (IL)-6, and -1082 (G/A) IL-10 promoter polymorphisms by Polymerase Chain Reaction Sequence Specific Primers technique.Results: We observed different genotype and allele distributions of TNF-alpha, IFN-gamma, and IL-10 polymorphisms in the three groups of patients analyzed. In particular, bipolar 11 patients were characterized by an absence of adenine (A) high producer allele of TNF-alpha (P