Orthopaedic manifestations of chronic graft-versus-host disease
Orthopaedic manifestations of chronic graft-versus-host disease
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DOI：
10.1097/00004694-199809000-00002
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发表时间：
1998-09-01
影响因子：
1.7
通讯作者：
August, C
中科院分区：
文献类型：
--
作者：
Beredjiklian, PK;Drummond, DS;August, C
Chronic graft-versus-host disease (GVHD) is a well-recognized complication of allogeneic bone marrow transplantation (BMT). Musculoskeletal manifestations include joint contractures, polymyositis, polyserositis, and fasciitis. We present 14 patients with orthopaedic complications of chronic GVHD. Long-term conservative management of joint contractures with physical therapy and orthotics was generally successful in restoring patients' premorbid functional status. Surgical release of joint contractures yielded poor results and rendered the affected joints unresponsive to further conservative treatment. Surgical intervention in the treatment of joint contractures resulting from chronic GVHD does not appear qualitatively to improve functional status in patients affected with this disease process.
