Dysfunction of thermoregulation contributes to the generation of hyperthermia-induced seizures
Dysfunction of thermoregulation contributes to the generation of hyperthermia-induced seizures
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体温调节功能障碍导致高热引起的癫痫发作
DOI：
10.1016/j.neulet.2014.08.037
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发表时间：
2014-10-03
影响因子：
2.5
通讯作者：
Chen，Zhong
中科院分区：
文献类型：
--
作者：
Feng，Bo;Tang，Yang-Shun;Chen，Zhong
热性惊厥（FS）通常定义为在发热期间发生的惊厥。长期预后，包括癫痫和认知功能畸形的发展，已被证明后婴儿FS。然而，高温环境下诱发癫痫发作的机制尚不清楚。我们在这里发现，经历实验性FS的大鼠幼仔的体温在从高温环境中移除后显著降低（128 °C）。无论是消除癫痫发作的产生和癫痫发作后的温度下降与氯丙嗪（CPZ），这损害了体温调节，或通过视前区和下丘脑前部（PO/AH）的电解质损伤的预处理。然而，非甾体抗炎药塞来昔布并不影响癫痫发作的发生率和癫痫发作后体温的下降。此外，戊巴比妥可防止癫痫发作的发生，但不能逆转FS后体温的下降。因此，我们的工作表明，体温过度调节发生在高温环境中，和PO/AH的体温调节功能障碍，高温后FS的产生。
Febrile seizures (FS) are generally defined as seizures taking place during fever. Long-term prognosis, including development of epilepsy and malformation of cognitive function, has been demonstrated after infantile FS. However, the mechanism that triggers seizures in hyperthermic environment is still unclear. We here found that the body temperature of rat pups that experienced experimental FS was markedly decreased (∼28 °C) after they were removed from the hyperthermic environment. Both the seizure generation and the temperature drop after seizure attack were abolished by either pre-treatment with chlorpromazine (CPZ), which impairs the thermoregulation, or by an electrolytic lesion of the preoptic area and anterior hypothalamus (PO/AH). However, the non-steroidal anti-inflammatory drug celecoxib did not affect the seizure incidence and the decrease in body temperature after seizure attack. In addition, pentobarbital prevented the generation of seizures, but did not reverse the decrease of body temperature after FS. Therefore, our work indicates that an over-regulation of body temperature occurs during hyperthermic environment, and that the dysfunction of thermoregulation in the PO/AH following hyperthermia contributes to the generation of FS.