A paradigm for the development and evaluation of novel implant topologies for bone fixation: implant design and fabrication.
A paradigm for the development and evaluation of novel implant topologies for bone fixation: implant design and fabrication.
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DOI：
10.1016/j.jbiomech.2012.06.011
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发表时间：
2012-08
影响因子：
2.4
通讯作者：
Heesuk Kang;J. P. Long;Gary D Urbiel Goldner;S. Goldstein;S. Hollister
中科院分区：
文献类型：
--
作者：
Heesuk Kang;J. P. Long;Gary D Urbiel Goldner;S. Goldstein;S. Hollister
生物集成装置的未来发展将改善机器人假肢的功能。生物集成假体发展的关键一步将是建立与残骨的长期、安全固定。为了克服与当代骨锚定假肢相关的局限性，我们建立了一个范式，用于开发和制造承受特定载荷的新型骨科植入物。拓扑优化方案用于生成最佳植入物宏观结构，使骨-植入物界面附近的变形最小化。在植入物的特性和界面连接的变化进行了研究，以检查这些变量如何影响优化的植入物的布局。为了增强组织整合，通过引入优化的微观结构进一步修改了钛（Ti）合金植入物的优化设计宏观几何形状。采用选择性激光烧结（SLS）技术成功制造了所选植入物的复杂几何形状。通过将制造的植入物的体积和横截面积与CAD数据进行比较来评估制造精度。制造体积与CAD设计体积的误差小于8%，制造植入物的SEM图像与CAD设计的相应横截面之间的横截面积差异平均小于9%。我们已经证明，这种计算设计方法，结合固体自由成型制造技术，提供了一种通用的方式来开发新的骨科植入物。
The future development of bio-integrated devices will improve the functionality of robotic prosthetic limbs. A critical step in the advancement of bio-integrated prostheses will be establishing long-term, secure fixation to the remnant bone. To overcome limitations associated with contemporary bone-anchored prosthetic limbs, we established a paradigm for developing and fabricating novel orthopedic implants undergoing specified loading. A topology optimization scheme was utilized to generate optimal implant macrostructures that minimize deformations near the bone-implant interface. Variations in implant characteristics and interfacial connectivity were investigated to examine how these variables influence the layout of the optimized implant. For enhanced tissue integration, the optimally designed macroscopic geometry of a titanium (Ti)-alloy implant was further modified by introducing optimized microstructures. The complex geometries of selected implants were successfully fabricated using selective laser sintering (SLS) technology. Fabrication accuracy was assessed by comparing volumes and cross-sectional areas of fabricated implants to CAD data. The error of fabricated volume to CAD design volume was less than 8% and differences in cross sectional areas between SEM images of fabricated implants and corresponding cross sections from CAD design were on average less than 9%. We have demonstrated that this computational design method, combined with solid freeform fabrication techniques, provides a versatile way to develop novel orthopedic implants.