Synthesis of CaO2 Nanocrystals and Their Spherical Aggregates with Uniform Sizes for Use as a Biodegradable Bacteriostatic Agent
Synthesis of CaO2 Nanocrystals and Their Spherical Aggregates with Uniform Sizes for Use as a Biodegradable Bacteriostatic Agent
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DOI：
10.1002/smll.201902118
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发表时间：
2019-07-22
期刊：
影响因子：
13.3
通讯作者：
Xia, Younan
中科院分区：
文献类型：
--
作者：
Shen, Song;Mamat, Marhaba;Xia, Younan
作为O-2和过氧化氢（H2O2）的固体前体，过氧化钙（CaO2）已被广泛应用于消毒和污染物降解。然而，由于缺乏均匀的纳米颗粒，极大地限制了这种材料在与医学相关的其他应用中的潜在用途。本文报道了一种简便合成具有均匀可控尺寸的氧化钙纳米晶体及其球形聚集体的新方法。在乙醇中，CaCl2与H2O2反应生成2- 15nm大小的CaO2原生纳米晶体，并在聚乙烯基吡罗烷酮（PVP）的辅助下聚集成均匀的球形颗粒。通过改变CaCl2和/或PVP的浓度，可以很容易地将球形聚集体的平均直径调整在15-100 nm的范围内。对于粒径较小的球形聚集体，它们在接触水时释放H2O2和O-2的速度更快，从而具有更好的抗菌活性。该研究不仅为均匀氧化钙纳米晶体及其球形聚集体的合成提供了一条新途径，而且为具有生物降解性的抑菌剂提供了前景。
As a solid precursor to O-2 and hydrogen peroxide (H2O2), calcium peroxide (CaO2) has found widespread use in applications related to disinfection and contaminant degradation. The lack of uniform nanoparticles, however, greatly limits the potential use of this material in other applications related to medicine. Here, a new route to the facile synthesis of CaO2 nanocrystals and their spherical aggregates with uniform, controllable sizes is reported. The synthesis involves the reaction between CaCl2 and H2O2 to generate CaO2 primary nanocrystals of 2-15 nm in size in ethanol, followed by their aggregation into uniform, spherical particles with the aid of poly(vinyl pyrrolidone) (PVP). The average diameter of the spherical aggregates can be easily tuned in the range of 15-100 nm by varying the concentrations of CaCl2 and/or PVP. For the spherical aggregates with a smaller size, they release H2O2 and O-2 more quickly when exposed to water, resulting in superior antimicrobial activity. This study not only demonstrates a new route to the synthesis of uniform CaO2 nanocrystals and their spherical aggregates but also offers a promising bacteriostatic agent with biodegradability.