Singlet oxygen luminescence detection with a fiber-coupled superconducting nanowire single-photon detector
Singlet oxygen luminescence detection with a fiber-coupled superconducting nanowire single-photon detector
复制标题
DOI：
10.1364/oe.21.005005
复制
发表时间：
2013-02-25
期刊：
影响因子：
3.8
通讯作者：
Hadfield, Robert H.
中科院分区：
文献类型：
--
作者：
Gemmell, Nathan R.;McCarthy, Aongus;Hadfield, Robert H.
单线态氧（O-1（2））发光的直接监测是一个特别具有挑战性的红外光电探测问题。O-1（2）是氧分子的激发态，是许多生物过程中的关键中间体。我们采用低噪声超导纳米线单光子探测器在1270 nm波长处记录了一种模型光敏剂（玫瑰红）在溶液中的O-1（2）发光。利用窄带光谱滤波和化学猝灭验证了O-1（2）信号，并研究了蛋白质的加入对寿命的影响。此外，我们证明了通过单根光纤检测O-1（2）发光，这是光动力治疗等临床治疗中剂量监测的显著进步。(C)2013年美国光学学会
Direct monitoring of singlet oxygen (O-1(2)) luminescence is a particularly challenging infrared photodetection problem. O-1(2), an excited state of the oxygen molecule, is a crucial intermediate in many biological processes. We employ a low noise superconducting nanowire single-photon detector to record O-1(2) luminescence at 1270 nm wavelength from a model photosensitizer (Rose Bengal) in solution. Narrow band spectral filtering and chemical quenching is used to verify the O-1(2) signal, and lifetime evolution with the addition of protein is studied. Furthermore, we demonstrate the detection of O-1(2) luminescence through a single optical fiber, a marked advance for dose monitoring in clinical treatments such as photodynamic therapy. (C) 2013 Optical Society of America