Combined PD-1/PD-L1 and tumor-infiltrating immune cells redefined a unique molecular subtype of high-grade serous ovarian carcinoma.
Combined PD-1/PD-L1 and tumor-infiltrating immune cells redefined a unique molecular subtype of high-grade serous ovarian carcinoma.
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程序性死亡受体1（PD-1）/程序性死亡受体配体1（PD-L1）与肿瘤浸润免疫细胞相结合，重新定义了高级别浆液性卵巢癌的一种独特分子亚型。
DOI：
10.1186/s12864-021-08265-y
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发表时间：
2022-01-13
期刊：
影响因子：
4.4
通讯作者：
Jia W
中科院分区：
文献类型：
--
作者：
Liu P;Chen R;Zhang X;Fu R;Tao L;Jia W
高级别浆液性卵巢癌是高度异质性的，尽管已经进行了许多研究来鉴定对免疫治疗敏感的高级别浆液性卵巢癌分子亚型，但迄今为止还没有提出精确的分子亚型。免疫细胞浸润和免疫检查点与免疫治疗高度相关。在这里，我们研究了免疫细胞浸润和免疫检查点值的预后和精确的免疫治疗高级别浆液性卵巢癌的分子亚型分类的基础上。在免疫细胞浸润谱中鉴定出“高级别浆液性卵巢癌的高抗原呈递细胞浸润分子亚型”。三个免疫细胞浸润簇（A、B和C）中的每一个都表现出不同的免疫细胞表征，其中免疫细胞浸润簇C表现出高抗原呈递细胞浸润、改善的预后和对免疫疗法的更高敏感性。程序性死亡-1/程序性死亡配体1具有预后和预测作用，可以帮助分类分子亚型。我们的研究结果重新定义了一种独特的高级别浆液性卵巢癌的分子亚型，这表明具有较高抗原呈递细胞浸润和程序性死亡-1/程序性死亡配体1表达的高级别浆液性卵巢癌患者可以从精确的免疫治疗中获益。在线版本包含补充材料，可通过10.1186/s12864-021-08265-y获得。
High-grade serous ovarian carcinoma is highly heterogeneous, and although many studies have been conducted to identify high-grade serous ovarian carcinoma molecular subtypes that are sensitive to immunotherapy, no precise molecular subtype has been proposed to date. Immune cell infiltration and immune checkpoints are highly correlated with immunotherapy. Here, we investigated immune cell infiltration and immune checkpoint values for prognosis and precise immunotherapy for high-grade serous ovarian carcinoma based on molecular subtype classification. “High antigen-presenting cells infiltration molecular subtype of high-grade serous ovarian carcinoma” was identified in immune cell infiltration profiles. Each of the three immune cell infiltration clusters (A, B, and C) demonstrated distinct immune cell characterization, with immune cell infiltration cluster C exhibiting high antigen-presenting cell infiltration, improved prognosis, and higher sensitivity to immunotherapy. Programmed death-1/programmed death ligand 1 has a prognostic and predictive role that can help classify molecular subtypes. Our findings redefined a unique molecular subtype of high-grade serous ovarian carcinoma, suggesting that high-grade serous ovarian carcinoma patients with higher antigen-presenting cell infiltration and programmed death-1/programmed death ligand 1 expression can benefit from precise immunotherapy. The online version contains supplementary material available at 10.1186/s12864-021-08265-y.
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影响因子：
64.8
作者：
通讯作者：
--
影响因子：
--
作者：
Darb-Esfahani S;Kunze CA;Kulbe H;Sehouli J;Wienert S;Lindner J;Budczies J;Bockmayr M;Dietel M;Denkert C;Braicu I;Jöhrens K
通讯作者：
Jöhrens K
影响因子：
8.4
作者：
Droeser, Raoul A.;Hirt, Christian;Tornillo, Luigi
通讯作者：
Tornillo, Luigi
影响因子：
4.7
作者：
Kim, Hyun-Soo;Kim, Ji-Ye;Kim, Young Tae
通讯作者：
Kim, Young Tae
影响因子：
11.5
作者：
Fucikova, Jitka;Rakova, Jana;Spisek, Radek
通讯作者：
Spisek, Radek