FEVER PRODUCED BY INTRAHYPOTHALAMIC INJECTION OF INTERLEUKIN-1 AND INTERLEUKIN-6
FEVER PRODUCED BY INTRAHYPOTHALAMIC INJECTION OF INTERLEUKIN-1 AND INTERLEUKIN-6
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DOI：
10.1016/1043-4666(91)90016-7
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发表时间：
1991-05-01
期刊：
影响因子：
3.8
通讯作者：
BILLIAU, A
中科院分区：
文献类型：
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作者：
LESNIKOV, VA;EFREMOV, OM;BILLIAU, A
天然来源的纯人白细胞介素-1 β（IL-1β）和白细胞介素-6（IL-6）被发现当注射到脑的PO/AH区域时引起家兔发热。该效应所需的阈值剂量为0.4至4 U，相当于IL-1β的0.04至0.4 ng，约为50 U，相当于IL-6的0.05 ng。由此估计，该脑区域对约1 ng/ml的这些细胞因子的局部浓度作出反应，该水平在静脉内施用任一细胞因子的阈值致热剂量后可以容易地达到。这一观察结果支持了这样的观点，即由全身内源性IL-1和IL-6产生引起的发热是由于对体温调节中心的直接影响，可能不需要在远离该中心的部位产生介质，如白藜芦醇。
Pure human interleukin-1β (IL-1β) and interleukin-6 (IL-6), both of natural origin, were found to cause fever in rabbits when injected into the PO/AH region of the brain. The threshold dose required for this effect was between 0.4 and 4 U, equivalent to 0.04 to 0.4 ng for IL-1β, and around 50 U, equivalent to 0.05 ng for IL-6. From this it was estimated that this area of the brain responds to a local concentration of approximately 1 ng/ml of these cytokines, a level which can easily be reached after intravenous administration of threshold pyrogenic doses of either cytokine. The observation supports the view that fever induced by systemic endogenous production of IL-1 and IL-6 is due to a direct effect on the thermoregulatory center and may not require production of mediators, such as prostaglandins, at sites distant from the center.