The cortical neuroanatomy of neuropsychological deficits in mild cognitive impairment and Alzheimer's disease: A surface-based morphometric analysis
The cortical neuroanatomy of neuropsychological deficits in mild cognitive impairment and Alzheimer's disease: A surface-based morphometric analysis
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DOI：
10.1016/j.neuropsychologia.2011.10.010
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发表时间：
2011-12-01
期刊：
影响因子：
2.6
通讯作者：
Na, Duk L.
中科院分区：
文献类型：
--
作者：
Ahn, Hyun-Jung;Seo, Sang Won;Na, Duk L.
可能患有阿尔茨海默病（AD）和轻度认知障碍（aMCI）的健忘症形式的患者通常表现出几种类型的神经心理缺陷。这些缺陷通常与神经元退化引起的皮质萎缩有关。本研究的目的是探讨不同的解剖模式的皮质萎缩是否与特定的神经心理缺陷。参与者包括170名AD患者和99名aMCI患者。所有参与者都接受了首尔神经心理筛选组合（SNSB），其中包括评估注意力、语言、视觉空间功能、言语和视觉记忆以及额叶/执行功能的测试。皮质萎缩（变薄）通过使用自动化三维磁共振成像测量整个大脑的皮质套厚度来量化。皮质厚度和神经心理性能之间的关系进行了分析，采用逐步多元线性回归分析。这些分析（校正P <0.001）表明，几个特定的大脑区域与皮质变薄与认知功能障碍有关，包括：数字跨度向后，言语和图片回忆，命名和流畅性，绘画复制，反应抑制和选择性注意。然而，其他一些功能与特定的皮质萎缩灶无关（数字向前延伸、Stroop测试的单词阅读部分、单词和图片识别）。我们的研究，涉及大样本的参与者与aMCI和AD，提供了支持的假设，皮质变薄萎缩在特定的解剖位点的病理标志物的特定形式的认知功能障碍。(C)2011爱思唯尔有限公司保留所有权利。
Patients with probable Alzheimer's disease (AD) and the amnesic form of mild cognitive impairment (aMCI) often demonstrate several types of neuropsychological deficits. These deficits are often related to cortical atrophy, induced by neuronal degradation. The purpose of this study is to investigate whether different anatomic patterns of cortical atrophy are associated with specific neuropsychological deficits. The participants were 170 patients with AD and 99 patients with aMCI. All participants underwent the Seoul Neuropsychological Screening Battery (SNSB), which includes tests that assess attention, language, visuospatial functions, verbal and visual memory, and frontal/executive functions. Cortical atrophy (thinning) was quantified by measuring the thickness of the cortical mantle across the entire brain using automated, three-dimensional magnetic resonance imaging. The relationship between cortical thickness and neuropsychological performance was analysed using stepwise multiple linear regression analyses. These analyses (corrected P < .001) showed that several specific brain regions with cortical thinning were associated with cognitive dysfunction including: digit span backward, verbal and picture recall, naming and fluency, drawing-copying, response inhibition and selective attention. Some of the other functions, however, were not associated with specific foci of cortical atrophy (digit span forward, the word reading portion of the Stroop test, word and picture recognition). Our study, involving a large sample of participants with aMCI and AD, provides support for the postulate that cortical thinning-atrophy in specific anatomic loci are pathological markers for specific forms of cognitive dysfunction. (C) 2011 Elsevier Ltd. All rights reserved.