What is a clinically relevant change on the HIT-6 questionnaire? An estimation in a primary-care population of migraine patients
What is a clinically relevant change on the HIT-6 questionnaire? An estimation in a primary-care population of migraine patients
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DOI：
10.1177/0333102413497599
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发表时间：
2014-01-01
期刊：
影响因子：
4.9
通讯作者：
Blom, Jeanet W.
中科院分区：
文献类型：
--
作者：
Smelt, Antonia F. H.;Assendelft, Willem J. J.;Blom, Jeanet W.
目的为了解释问卷评分，临床医生和研究人员需要知道评分的变化反映了个体患者状况的有意义的变化，以及哪些差异反映了组间有意义的差异。这些值在不同人群之间存在差异。我们确定了人内最低限度的重要变化（MIC）和组间最低限度的重要差异（MID）的头痛影响测试-6（HIT-6）问卷调查的偏头痛patients.Methods的初级保健人群中，我们包括490例患者谁参加了偏头痛的治疗在初级保健的临床试验。我们比较了基线和3个月随访时他们在HIT-6问卷上的变化分数，并根据平均变化方法和ROC曲线方法对两个锚问题进行了回答。人内MIC值的选择取决于特定环境中假阳性和假阴性的后果。组间MID估计为-1.5points.Conclusions我们确定了在偏头痛患者的初级保健人群中HIT-6的人内MIC和组间MID。我们建议将这些值用于临床护理和研究。
Objective To interpret questionnaire scores, clinicians and researchers need to know what change in score reflects a meaningful change in the condition of an individual patient, and what difference reflects a meaningful difference between groups. These values differ between different populations. We determined the within-person minimally important change (MIC) and the between-group minimally important difference (MID) of the Headache Impact Test-6 (HIT-6) questionnaire in a primary-care population of migraine patients.Methods We included 490 patients who participated in a clinical trial on the treatment of migraine in primary care. We compared their change scores on the HIT-6 questionnaire between baseline and at three-months follow-up with the answers to two anchor questions according to the mean change approach' and the ROC curve approach'.Results The within-person MIC was estimated to be between -2.5 points (mean change approach) and -6 points (ROC curve approach). The choice for the within-person MIC value depends on the consequences of false positives and false negatives in a particular setting. The between-group MID was estimated at -1.5 points.Conclusions We determined the within-person MIC and between-group MID for the HIT-6 in a primary-care population of migraine patients. We recommend the use of these values for clinical care and for research.