Occlusion of the MCA by an intraluminal filament may cause disturbances in the hippocampal blood flow due to anomalies of circle of Willis and filament thickness
Occlusion of the MCA by an intraluminal filament may cause disturbances in the hippocampal blood flow due to anomalies of circle of Willis and filament thickness
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DOI：
10.1016/s0006-8993(99)01175-0
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发表时间：
1999-03-20
期刊：
影响因子：
2.9
通讯作者：
Dalkara, T
中科院分区：
文献类型：
--
作者：
Gursoy-Özdemir, Y;Bolay, H;Dalkara, T
我们在瑞士白化小鼠和SV - 129小鼠（n = 67）以及Wistar大鼠（n = 64）中，通过丝线阻塞大脑中动脉（MCA）来检测海马体的血流变化和组织学情况。用炭黑填充脑动脉显示，50%的瑞士小鼠的一条或两条后交通动脉发育不全。当这些小鼠经历2小时大脑中动脉阻塞和22小时再灌注时，用2,3,5 - 氯化三苯基四氮唑或苏木精 - 伊红染色在同侧海马体中检测到缺血性变化。在SV - 129小鼠和Wistar大鼠（除一只外）中未发现此类异常。当用6/0尼龙丝线阻塞大脑中动脉时，在Willis环正常的小鼠中，海马血流降至基线的60±2.3%，而在Willis环不完整的小鼠中降至37±4.2%。当使用8/0丝线时，在Willis环正常的小鼠中未观察到血流变化，但在Willis环不完整的小鼠中血流降至60±2%。当使用3/0丝线时，在Wistar大鼠中也观察到血流降至63±4%。这些数据表明，用粗丝线阻塞大脑中动脉可能导致海马体血流减少，如果Willis环异常，这种减少可能严重到足以导致梗死。（C）1999年，由爱思唯尔科学出版社出版。保留所有权利。
We examined blood flow changes and histology in the hippocampus induced by occlusion of the middle cerebral artery (MCA) by a filament in Swiss albino and SV-129 mice (n = 67) and in Wistar rats (n = 64). Filling cerebral arteries with carbon black revealed that one or both posterior communicating arteries were hypoplastic in 50% of Swiss mice. Ischemic changes were detected in the ipsilateral hippocampus with 2,3,5-triphenyl tetrazolium chloride or hematoxylin and eosin staining when these mice were subjected to 2-h MCA occlusion and 22-h reperfusion. No such abnormalities were found in SV-129 mice and Wistar rats (except one). The hippocampal blood flow dropped Co 60 +/-: 2.3% of the baseline in mice with a normal circle of Willis but to 37 +/- 4.2% in those with an incomplete circle when the MCA was occluded with a 6/0 nylon filament. When an 8/0 filament was used, no flow change in mice with a normal circle but a decrease to 60 +/- 2% in those with an incomplete circle was observed. A flow drop to 63 +/- 4% was also seen in Wistar rats when a 3/0 filament used. These data demonstrate that occlusion of the MCA by a thick filament may cause flow reduction in the hippocampus, which may be severe enough to lead to infarction if the circle of Willis is anomalous. (C) 1999 Published by Elsevier Science B.V. All rights reserved.