MEMBRANE CURRENTS IN ISOLATED FROG NERVE FIBRE UNDER VOLTAGE CLAMP CONDITIONS
MEMBRANE CURRENTS IN ISOLATED FROG NERVE FIBRE UNDER VOLTAGE CLAMP CONDITIONS
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DOI：
10.1113/jphysiol.1958.sp006045
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发表时间：
1958-01-01
影响因子：
5.5
通讯作者：
FRANKENHAEUSER, B
中科院分区：
文献类型：
--
作者：
DODGE, FA;FRANKENHAEUSER, B
本文介绍了一种稳定蛙神经纤维膜电位的方法及其局限性。该方法涉及使用2个反馈放大器系统来测量膜电位并将膜电位稳定在期望值。与阶跃极化的膜电流的定性描述，并详细描述的电流的属性。青蛙神经所描述的膜电流是类似于鱿鱼纤维中观察到的，这表明青蛙神经，去极化时，经历特定的膜电导的变化，这是非常相似的发生在鱿鱼巨大的神经纤维。
A method of stabilizing the membrane potential of an isolated frog nerve fiber and its limitations are described. The method involves use of 2 feedback amplifier systems for measuring the membrane potential and for stabilizing the membrane potential at desired values. A qualitative description of the membrane currents associated with step polarizations is presented and the properties of the currents are described in detail. The membrane currents described for frog nerve are similar to those observed in squid fiber suggesting that the frog nerve, when depolarized, undergoes specific changes in membrane conductance which are very similar to those occurring in the squid giant nerve fiber.