Fusing Sensor Paradigms to Acquire Chemical Information: An Integrative Role for Smart Biopolymeric Hydrogels.
Fusing Sensor Paradigms to Acquire Chemical Information: An Integrative Role for Smart Biopolymeric Hydrogels.
复制标题
DOI：
10.1002/adhm.201600516
复制
发表时间：
2016-10
影响因子：
10
通讯作者：
Payne GF
中科院分区：
文献类型：
--
作者：
Kim E;Liu Y;Ben-Yoav H;Winkler TE;Yan K;Shi X;Shen J;Kelly DL;Ghodssi R;Bentley WE;Payne GF
信息时代改变了我们的生活，但令人惊讶的是，它对化学信息（例如来自我们生物世界的化学信息）的获取、分析和交流方式影响甚微。传感器系统有望通过提供对化学信息的快速获取来改变这种状况。这种获取将得益于各个领域的技术进步：生物学使分子识别元件的合成、设计和发现以及基于细胞的信号处理器的产生成为可能；物理学和化学提供了纳米组件，促进了富含化学信息的信号的传输和转换；微加工技术正在生产能够通过各种方式接收这些信号的传感器；信号处理分析提高了化学信息的提取能力。作者认为，功能性传感器系统发展的关键将是以下材料：（i）能够对各种传感组件（用于化学识别和信号转换）进行集成和分级组装；（ii）促进不同方式之间有意义的通信。有人提出，刺激响应性自组装生物聚合物能够执行此类集成功能，而氧化还原提供了跨方式的通信能力。利用开发用于治疗精神分裂症的电化学传感器的最新进展来说明利用传感器进行化学信息处理的机遇和挑战。
The Information Age transformed our lives but it has had surprisingly little impact on the way chemical information (e.g., from our biological world) is acquired, analyzed and communicated. Sensor systems are poised to change this situation by providing rapid access to chemical information. This access will be enabled by technological advances from various fields: biology enables the synthesis, design and discovery of molecular recognition elements as well as the generation of cell-based signal processors; physics and chemistry are providing nano-components that facilitate the transmission and transduction of signals rich with chemical information; microfabrication is yielding sensors capable of receiving these signals through various modalities; and signal processing analysis enhances the extraction of chemical information. The authors contend that integral to the development of functional sensor systems will be materials that (i) enable the integrative and hierarchical assembly of various sensing components (for chemical recognition and signal transduction) and (ii) facilitate meaningful communication across modalities. It is suggested that stimuli-responsive self-assembling biopolymers can perform such integrative functions, and redox provides modality-spanning communication capabilities. Recent progress toward the development of electrochemical sensors to manage schizophrenia is used to illustrate the opportunities and challenges for enlisting sensors for chemical information processing.