Viral and cellular contributions to herpes simplex virus entry into the cell
Viral and cellular contributions to herpes simplex virus entry into the cell
复制标题
DOI：
10.1016/j.coviro.2011.12.001
复制
发表时间：
2012-02-01
影响因子：
5.9
通讯作者：
Gianni, Tatiana
中科院分区：
文献类型：
--
作者：
Campadelli-Fiume, Gabriella;Menotti, Laura;Gianni, Tatiana
单纯疱疹病毒 (HSV) 进入细胞涉及病毒粒子包膜与细胞膜的融合，以及将衣壳和外皮蛋白递送至细胞质。近年来，我们对这一现象的了解大大增加。在病毒方面，进入融合机制（由糖蛋白 gD、异二聚体 gH/gL 和 gB 组成）的多部分性质需要一种由 gD 与其受体之一相遇促进的 gD 激活机制；以及进入融合糖蛋白之间的串扰，最终导致 gB 激活和融合执行。在细胞方面，机器和信号活动已就位。已知受体和哨兵的数量正在增加。细胞通过路由因子通过替代进入途径引导病毒，例如αVβ3-整联蛋白和配对的免疫球蛋白样2型受体α。在信号事件中，关键的一个是宿主对传入病毒体的立即反应。出乎意料的是，这部分是由相同的病毒体成分和一些也促进病毒进入的细胞因素触发的。因此，迄今为止被认为截然不同的两种现象之间正在出现联系。
Herpes simplex virus (HSV) entry into the cell involves the fusion of the virion envelope with a cellular membrane and delivery of capsid and tegument proteins to the cytoplasm. Our understanding of this phenomenon has greatly increased in recent years. On the virus side, the multipartite nature of the entry-fusion machinery (made of the glycoproteins gD, the heterodimer gH/gL and gB) entails a mechanism of gD activation promoted by the gD encounter with one of its receptor; and cross-talk among the entry-fusion glycoproteins, which culminates in gB activation and fusion execution. On the cell side, machineries and signalling activities are put in place. The number of known receptors and sentinels is increasing. The cell routes the virus through alternative entry pathways by means of routing factors, exemplified by alpha V beta 3-integrin and paired immunoglobulin-like type 2 receptor alpha. Of the signalling events, a key one is the immediate host response to incoming virions. Unexpectedly, this is in part triggered by the same virion components and some cellular factors that also promote virus entry. Hence, a link is emerging between two phenomena so far considered as distinct.