Transcriptional regulation of T cell metabolism.
Transcriptional regulation of T cell metabolism.
复制标题
T细胞代谢的转录调节。
DOI：
10.1016/j.molimm.2015.07.038
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发表时间：
2015-12
影响因子：
3.6
通讯作者：
Weinmann AS
中科院分区：
文献类型：
--
作者：
Hough KP;Chisolm DA;Weinmann AS
T细胞表达特定的代谢程序，以促进不同的细胞分化状态。幼稚T细胞的活化上调编码糖酵解、β-内酰胺分解和脂质生物合成途径的组分的基因的表达，以促进稳健的增殖和效应T细胞活性。相比之下，记忆T细胞下调这些途径，主要依赖于分解代谢途径的长期生存。编码代谢途径组分的基因表达的动态变化部分地定义了在不同的T细胞状态中利用哪些代谢程序。目前的数据表明，参与T细胞特化决定的关键转录因子，包括T-bet，Bcl-6，HIF 1，IRF 4和Myc，将细胞代谢的选择性编程与命运决定联系起来。在这篇综述中，我们将突出转录调控事件，定义参与效应和记忆T细胞分化的代谢途径。
T cells express specific metabolic programs to promote diverse cellular differentiation states. The activation of naïve T cells upregulates the expression of genes encoding components of the glycolysis, glutaminolysis, and lipid biosynthesis pathways to promote robust proliferation and effector T cell activity. In contrast, memory T cells downregulate these pathways and predominantly rely on catabolic pathways for long-term survival. Dynamic changes in the expression of the genes encoding components of metabolic pathways in part define which metabolic programs are utilized in diverse T cell states. The current data suggest that key transcription factors involved in T cell specialization decisions, including T-bet, Bcl-6, HIF1, IRF4 and Myc, link the selective programming of cellular metabolism with fate decisions. In this review, we will highlight the transcriptional regulatory events that define metabolic pathways involved in effector and memory T cell differentiation.