Temporal circuit of macroscale dynamic brain activity supports human consciousness
Temporal circuit of macroscale dynamic brain activity supports human consciousness
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DOI：
10.1126/sciadv.aaz0087
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发表时间：
2020-03-01
期刊：
影响因子：
13.6
通讯作者：
Hudetz, Anthony G.
中科院分区：
文献类型：
--
作者：
Huang, Zirui;Zhang, Jun;Hudetz, Anthony G.
人类意识的持续流依赖于两个不同的皮层系统，默认模式网络和背侧注意网络，它们以与大脑相关的方式交替活动。我们研究了这两个系统在意识大脑中是如何调节的，以及当意识减弱时它们是如何被破坏的。我们提供了证据的“时间电路”的特点是一组轨迹沿着动态大脑活动发生。我们表明，默认模式和背侧注意网络之间的过渡嵌入在这个时间电路，其中平衡的相互访问的大脑状态是意识的特点。相反，默认模式和背侧注意网络与时间回路的隔离与多种病因的无反应性相关。这些发现推进了对意识中与神经元相关的系统的功能作用的基本理解。
The ongoing stream of human consciousness relies on two distinct cortical systems, the default mode network and the dorsal attention network, which alternate their activity in an anticorrelated manner. We examined how the two systems are regulated in the conscious brain and how they are disrupted when consciousness is diminished. We provide evidence for a "temporal circuit" characterized by a set of trajectories along which dynamic brain activity occurs. We demonstrate that the transitions between default mode and dorsal attention networks are embedded in this temporal circuit, in which a balanced reciprocal accessibility of brain states is characteristic of consciousness. Conversely, isolation of the default mode and dorsal attention networks from the temporal circuit is associated with unresponsiveness of diverse etiologies. These findings advance the foundational understanding of the functional role of anticorrelated systems in consciousness.