Suppression of DNA repair by HTLV type 1 Tax correlates with Tax trans-activation of proliferating cell nuclear antigen gene expression.
Suppression of DNA repair by HTLV type 1 Tax correlates with Tax trans-activation of proliferating cell nuclear antigen gene expression.
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DOI：
10.1089/08892220050193056
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发表时间：
2000-11
影响因子：
1.5
通讯作者：
F. J. Lemoine;S. Kao;S. J. Marriott
中科院分区：
文献类型：
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作者：
F. J. Lemoine;S. Kao;S. J. Marriott
人类T细胞白血病病毒1型（HTLV-1）病毒癌蛋白Tax是一种影响病毒和细胞基因表达的转录反式激活因子。为了理解税收如何诱导转化，必须检查其改变细胞基因表达的能力的后果。我们之前已经证明，税收激活细胞基因的表达，增殖细胞核抗原（PCNA），税收抑制DNA修复。在这项研究中，我们测试了先前描述的Tax突变体激活PCNA基因表达的能力及其干扰DNA修复的能力。结果显示，PCNA基因表达的Tax反式激活与其通过核苷酸切除修复（NER）途径抑制DNA修复的能力之间存在很强的相关性。因此，激活PCNA基因表达的结果似乎是DNA修复能力的降低。税收的这些影响可能在其转型活动中发挥重要作用。
The human T cell leukemia virus type 1 (HTLV-1) viral oncoprotein Tax acts as a transcriptional trans-activator affecting viral as well as cellular gene expression. To understand how Tax induces transformation, the consequences of its ability to alter expression of cellular genes must be examined. We have previously demonstrated that Tax activates expression of the cellular gene, proliferating cell nuclear antigen (PCNA), and that Tax suppresses DNA repair. In this study we tested the ability of previously described Tax mutants to activate PCNA gene expression and their ability to interfere with DNA repair. The results revealed a strong correlation between Tax trans-activation of PCNA gene expression and its ability to inhibit DNA repair via the nucleotide excision repair (NER) pathway. Thus, a consequence of activated PCNA gene expression appears to be reduced DNA repair capacity. These effects of Tax are likely to play important roles in its transforming activity.