Yeast Prions Compared to Functional Prions and Amyloids.
Yeast Prions Compared to Functional Prions and Amyloids.
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DOI：
10.1016/j.jmb.2018.04.022
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发表时间：
2018-10
影响因子：
5.6
通讯作者：
R. Wickner;H. Edskes;Moonil Son;E. Bezsonov;Morgan DeWilde;Mathieu Ducatez
中科院分区：
文献类型：
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作者：
R. Wickner;H. Edskes;Moonil Son;E. Bezsonov;Morgan DeWilde;Mathieu Ducatez
酿酒酵母偶尔会寄生一系列的普鲁恩，大多数是基于一种正常溶解的蛋白质的自繁殖、自模板淀粉样丝。[URE3]是氮分解代谢调节因子Ure2p的一个Prion，而[PSI+]是翻译终止因子Sup35p的一个亚基Sup35p的Prion。与羊角孢霉的[Het-S]和酵母的[β]功能蛋白不同，基于淀粉的酵母蛋白在野生菌株中很少见，零星出现，具有单一蛋白序列的一系列Pron变体，具有折叠的平行β-Sheet淀粉样蛋白结构，对宿主有害，在宿主中引起应激反应，并受到各种宿主反蛋白系统的治愈。这些特征为区分功能性淀粉样蛋白/普恩蛋白和普恩蛋白疾病提供了逻辑基础。这些传染性酵母淀粉样变性是许多常见的基于淀粉样蛋白的疾病的杰出模型，这些疾病越来越多地被发现具有一些传染性特征。
Saccharomyces cerevisiae is an occasional host to an array of prions, most based on self-propagating, self-templating amyloid filaments of a normally soluble protein. [URE3] is a prion of Ure2p, a regulator of nitrogen catabolism, while [PSI +] is a prion of Sup35p, a subunit of the translation termination factor Sup35p. In contrast to the functional prions, [Het-s] of Podospora anserina and [BETA] of yeast, the amyloid-based yeast prions are rare in wild strains, arise sporadically, have an array of prion variants for a single prion protein sequence, have a folded in-register parallel β-sheet amyloid architecture, are detrimental to their hosts, arouse a stress response in the host, and are subject to curing by various host anti-prion systems. These characteristics allow a logical basis for distinction between functional amyloids/prions and prion diseases. These infectious yeast amyloidoses are outstanding models for the many common human amyloid-based diseases that are increasingly found to have some infectious characteristics.