From Stress to Postpartum Mood and Anxiety Disorders: How Chronic Peripartum Stress Can Impair Maternal Adaptations
From Stress to Postpartum Mood and Anxiety Disorders: How Chronic Peripartum Stress Can Impair Maternal Adaptations
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DOI：
10.1159/000330445
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发表时间：
2012-01-01
影响因子：
4.1
通讯作者：
Slattery, David A.
中科院分区：
文献类型：
--
作者：
Hillerer, Katharina M.;Neumann, Inga D.;Slattery, David A.
在所有哺乳动物物种中，围产期的特点是神经内分泌、分子和行为水平上的大量适应，这些适应为雌性应对母性的挑战做好了准备。这些变化已经得到了很好的描述，虽然它们对于确保后代的生存和养育是必要的，但人们越来越相信它们也是孕产妇心理健康所必需的。因此，虽然平静度增加和压力反应减弱是围产期的共同特征，但它也代表了对情绪障碍的敏感性增加的时期。虽然这些疾病的许多危险因素是已知的，但其潜在病因仍然知之甚少，至少部分原因是缺乏适当的动物模型。一种可转化的风险因素是围产期的压力暴露。在下面的综述中，我们首先描述常见的围产期适应以及产后情绪障碍对这些适应的影响。然后，我们讨论基础研究中描述的围产期压力暴露对母亲适应的已知后果。版权所有 (C) 2011 S. Karger AG，巴塞尔
The peripartum period, in all mammalian species, is characterised by numerous adaptations at neuroendocrine, molecular and behavioural levels that prepare the female for the challenges of motherhood. These changes have been well characterised and, while they are necessary to ensure the survival and nurturance of the offspring, there is growing belief that they are also required for maternal mental health. Thus, while increased calmness and attenuated stress responsivity are common characteristics of the peripartum period, it also represents a time of increased susceptibility to mood disorders. While a number of risk factors for these disorders are known, their underlying aetiology remains poorly understood, due at least in part to a lack of appropriate animal models. One translatable risk factor is stress exposure during the peripartum period. In the following review we first describe common peripartum adaptations and the impact postpartum mood disorders have on these. We then discuss the known consequences of peripartum stress exposure on such maternal adaptations that have been described in basic research. Copyright (C) 2011 S. Karger AG, Basel