Mesenchymal stem cells promote neutrophil activation by inducing IL-17 production in CD4+ CD45RO+ T cells
Mesenchymal stem cells promote neutrophil activation by inducing IL-17 production in CD4+ CD45RO+ T cells
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DOI：
10.1016/j.imbio.2012.02.007
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发表时间：
2013-01-01
期刊：
影响因子：
2.8
通讯作者：
Chen, Hsin-Wei
中科院分区：
文献类型：
--
作者：
Hsu, Shu-Ching;Wang, Li-Tzu;Chen, Hsin-Wei
间充质干细胞（MSC）是多能的，具有多种间充质谱系分化潜力和免疫调节能力。然而，间充质干细胞的免疫调节特性尚不明确。本研究的目的是阐明 MSC 在 IL-17 产生中的作用以及随后对中性粒细胞激活的影响。我们已经证明，人骨髓来源的间充质干细胞（BM-MSCs）能够指导抗CD3/抗CD28抗体激活的CD4（+）CD45RO（+）记忆T细胞，而不是其他CD4（+）子集或CD8（+）T细胞，在细胞与细胞接触后产生IL-17。添加IL-17后，中性粒细胞的吞噬活性增加。这是关于 BM-MSC 诱导记忆 CD4(+) T 细胞产生 IL-17 的能力的第一份报告，从而促进中性粒细胞吞噬活性的增强。这些结果表明MSCs通过调节CD4(+)CD45RO(+)记忆T细胞的IL-17来调节中性粒细胞的功能激活。 (C) 2012 爱思唯尔有限公司。版权所有。
Mesenchymal stem cells (MSCs) are multi-potent with numerous mesenchymal-lineage differentiation potential and immunomodulatory capabilities. However, the immunoregulatory properties of MSCs are not clearly defined. The objective of the present study was to elucidate the role(s) of MSCs in IL-17 production and the subsequent effect(s) on neutrophil activation. We have demonstrated that human bone marrow-derived MSCs (BM-MSCs) instruct anti-CD3/anti-CD28 antibody-activated CD4(+) CD45RO(+) memory T cells, but not other CD4(+) subsets or CD8(+) T cells, to produce IL-17 after cell-cell contact. After the addition of IL-17, neutrophil phagocytic activity was increased. This is the first report on the ability of BM-MSCs to induce IL-17 production in memory CD4(+) T cells that, in turn, promotes enhanced phagocytic activity of neutrophils. These results suggest that MSCs regulate the functional activation of neutrophils via their role in modulating IL-17 from CD4(+) CD45RO(+) memory T cells. (C) 2012 Elsevier GmbH. All rights reserved.