Policing of oncogene activity by p53
Policing of oncogene activity by p53
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DOI：
10.1038/443159a
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发表时间：
2006-09-14
期刊：
影响因子：
64.8
通讯作者：
Serrano, Manuel
中科院分区：
文献类型：
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作者：
Efeyan, Alejo;Garcia-Cao, Isabel;Serrano, Manuel
肿瘤抑制蛋白p53提供了最重要的基因防御癌症，并激活响应DNA损伤和致癌信号，这两个几乎普遍发生在恶性肿瘤。但这两种途径在诱导p53依赖性抗癌保护中的相对作用尚不清楚。在这里，我们表明，p53依赖性的抗癌保护作用在基因操作的小鼠中丢失，因此它们的p53在DNA损伤时被激活，而不是致癌信号。我们的结论是，致癌信号是关键事件，elp53依赖的保护和DNA损伤刺激是不太重要的。
The tumour-suppressor protein p53 provides the most important genetic defence against cancer and is activated in response to DNA damage and to oncogenic signalling, both of which occur almost universally in malignant tumours. But the relative contribution of these two pathways in inducing p53-dependent protection against cancer is unclear. Here we show that p53-dependent protection against cancer is lost in mice that have been genetically manipulated so that their p53 is activated in response to DNA damage but not to oncogenic signalling. We conclude that oncogenic signalling is the critical event that elicits p53-dependent protection and that the DNA-damage stimulus is less important.