AV3V neurons that send axons to hypothalamic nuclei respond to the systemic injection of IL-1beta.
AV3V neurons that send axons to hypothalamic nuclei respond to the systemic injection of IL-1beta.
复制标题
将轴突发送至下丘脑核团的 AV3V 神经元对全身注射 IL-1beta 做出反应。
DOI：
--
复制
发表时间：
1997
影响因子：
--
通讯作者：
Tetsuro Hori
中科院分区：
文献类型：
--
作者：
Kazuki Ota;T. Katafuchi;Atsushi Takaki;Tetsuro Hori
在乌拉坦和α-氯醛糖麻醉大鼠细胞外记录了第三脑室前腹侧区(AV3V)的单个神经元活动。电刺激内侧视前区(MPOA)和室旁核(PVN)显示AV3V和这些下丘脑核团之间有相互的神经联系，并具有同侧优势。全身注射IL-1β后，所有被mPOA或PVN反向激活的AV3V神经元的活动均发生改变。另一方面，在显示顺向反应的AV3V神经元中，只有大约60%受到IL-1β的影响。在9个AV3V神经元中，有7个经电生理证实可将轴突投射到mPOA或PVN，局部应用水杨酸钠可减弱重组人IL-1β引起的兴奋和抑制。这些结果表明，AV3V神经元对血液传播的IL-1β的反应至少部分是通过局部合成前列腺素来改变它们的活动，然后将信息发送到mPOA和PVN。
The single neuron activity in the anteroventral region of the third ventricle (AV3V) was extracellularly recorded in urethan and alpha-chloralose anesthetized rats. Electrical stimulation of the medial preoptic area (mPOA) and the paraventricular nucleus (PVN) revealed a reciprocal neural connection between the AV3V and these hypothalamic nuclei with an ipsilateral preponderance. All the AV3V neurons, which were antidromically activated by the stimulation of the mPOA or the PVN, altered their activity after the systemic injection of interleukin (IL)-1beta. On the other hand, only about 60% of the AV3V neurons that showed orthodromic responses were affected by IL-1beta. In seven of nine AV3V neurons that were electrophysiologically identified to send their axons to the mPOA or the PVN, the recombinant human IL-1beta-induced excitation and inhibition were attenuated by a local application of sodium salicylate through multibarreled micropipettes. These results suggest that the AV3V neurons alter their activity in response to the blood-borne IL-1beta, at least in part, through a local synthesis of prostanoids and then send the information to the mPOA and PVN.