Current knowledge of the roles of ghrelin in regulating food intake and energy balance in birds
Current knowledge of the roles of ghrelin in regulating food intake and energy balance in birds
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DOI：
10.1016/j.ygcen.2008.11.008
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发表时间：
2009-08-01
影响因子：
2.7
通讯作者：
Kangawa, Kenji
中科院分区：
文献类型：
--
作者：
Kaiya, Hiroyuki;Furuse, Mitsuhiro;Kangawa, Kenji
自从在大鼠胃中首次发现肽激素ghrelin以来，已经过去了十年。在此期间，ghrelin不仅在其他哺乳动物中被发现，而且在鱼类、两栖动物、爬行动物和鸟类中也被发现，其生理功能也得到了广泛的研究。2002年首次在鸡中鉴定出禽生长激素释放肽，迄今为止，已报道了六种不同的禽生长激素释放肽的氨基酸序列。在哺乳动物中，ghrelin是唯一已知的肠源性激素，当中枢或外周施用时刺激食物摄入。然而，在对鸡和鹌鹑的研究中，ghrelin在中央注射时抑制食物摄入，而ghrelin在外周注射引起的进食行为的影响是不确定的。本文综述了ghrelin对鸟类摄食和能量平衡的调节作用。(C)2008年爱思唯尔公司All rights reserved.
A decade has passed since the peptide hormone ghrelin was first discovered in rat stomach. During this period, ghrelin has been identified not only in other mammals but also in fish, amphibians, reptiles and birds, and its physiological functions have been widely investigated. Avian ghrelin was first identified in chickens in 2002 and to date, the amino acid sequences of six different avian ghrelin peptides have been reported. In mammals, ghrelin is the only known gut-derived hormone to stimulate food intake when administered centrally or peripherally. In studies on chickens and quail, however, ghrelin inhibits food intake when injected centrally, while the effects on feeding behavior elicited by ghrelin injected peripherally are equivocal. This review summarizes what is currently known about the regulation of food intake and energy balance by ghrelin in birds. (C) 2008 Elsevier Inc. All rights reserved.