Impact of Azadirachta indica Fruit Mucilage on particle size and swelling index in Central Composite Designed Acyclovir mucoadhesive microspheres
Impact of Azadirachta indica Fruit Mucilage on particle size and swelling index in Central Composite Designed Acyclovir mucoadhesive microspheres
复制标题
印楝果实粘液对中心复合设计的阿昔洛韦粘膜粘附微球粒径和溶胀指数的影响
DOI：
10.21123/bsj.2022.6786
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发表时间：
2022
影响因子：
0.6
通讯作者：
H. Ahad
中科院分区：
文献类型：
--
作者：
Gorantla Naresh Babu;Menaka Muthukaruppan;H. Ahad
：本次探索的目的是通过将印度苦楝 (Azadirachta indica) 果实粘液掺入粘膜粘附微球中，以阿昔洛韦 (AVR) 作为模型药物，研究其粘膜粘附特性。进行该研究是为了检查粘液比例对粒径和溶胀指数的影响。用不同比例的聚丙烯酸 934P 和印度果胶 (AIFM) 制备了九批 AVR 粘膜粘附微球。采用设计专家软件的中央复合材料设计，用于检查因变量（A. indica 粘液和聚丙烯酸 934 P 水平）对粒径和膨胀指数的影响作为响应。作为一致性研究的一部分，对这些批次的物理限制、AVR 含量和释放情况进行了检查。发现颗粒尺寸为35.2±0.3-48.1±0.6μm。与 B-5 中较大尺寸的颗粒相比，批次 B-1 中的颗粒尺寸最小。研究发现，粒径和溶胀指数取决于AIFM和聚丙烯酸的比例。研究发现AVR以受控方式系统释放，包封效果、粘膜粘附性、药物含量等约束条件良好。当制备成粘膜粘附微球时，阿昔洛韦能够通过聚丙烯酸 934P 实现良好的胃特异性药物递送，并通过 A. indica 果实粘液增强。扫描电子显微镜显示微球呈球形，表面相当光滑。
: The drive of this exploration is to investigate the mucoadhesive assets of A. indica ( Azadirachta indica ) fruit mucilage by incorporating it into mucoadhesive microspheres with Acyclovir (AVR) as a model drug. The study was performed to check the impact of the mucilage proportion on particle size and swelling index. Nine batches of AVR mucoadhesive microspheres were made with varying proportions of Polyacrylic acid 934P and A. indica fruit mucilage (AIFM). A central composite design with design expert software to check the impact of dependent variables ( A. indica mucilage and Polyacrylic acid 934 P levels) on particle size and swelling index as a response. As part of congeniality studies, the batches were examined for their physical constraints, AVR contents, and liberation. The particle size was found to be 35.2±0.3-48.1±0.6μm. In batch B-1, the particle was least sized compared to the larger size in B-5. The investigation found that the particle size and the swelling index depended on AIFM and Polyacrylic acid proportions. The research discovered that AVR was systematically released in a controlled manner and that the entrapment efficacy, mucoadhesion, drug content, and other constraints were found to be good. Acyclovir is capable of good stomach-specific drug delivery by Polyacrylic acid 934P and enhanced by A. indica fruit mucilage when prepared as mucoadhesive microspheres. Scanning electron microscopy reveals that the microspheres were spherical with a fairly smooth surface.