Relationship of Non-alcoholic Fatty Liver Disease With Cholecystectomy in the US Population
Relationship of Non-alcoholic Fatty Liver Disease With Cholecystectomy in the US Population
复制标题
DOI：
10.1038/ajg.2013.70
复制
发表时间：
2013-06-01
影响因子：
9.8
通讯作者：
Everhart, James E.
中科院分区：
文献类型：
--
作者：
Ruhl, Constance E.;Everhart, James E.
目的：除了与体重相关的疾病外，非酒精性脂肪性肝病（NAFLD）的危险因素尚不明确。我们在一项大型、全国性、以人群为基础的研究中调查了胆结石和胆囊切除术与 NAFLD 的关系。 方法：在 1988-1994 年第三次美国国家健康和营养检查调查的成年参与者中，对胆结石疾病进行了超声检查，随后对录像带进行了 NAFLD 的评估。使用逻辑回归分析计算胆结石疾病与 NAFLD 关联的优势比 (OR)，以调整常见相关因素。 结果：在 12,232 名没有病毒性肝炎或大量饮酒的参与者中，胆结石患病率为 7.4%，胆囊切除术为 5.6%，NAFLD 为 20.0%。接受胆囊切除术的参与者的 NAFLD 患病率（48.4%）比患有胆结石的参与者（34.4%）或没有胆结石疾病的参与者（17.9%）更高（P
OBJECTIVES: Other than weight-related conditions, risk factors for non-alcoholic fatty liver disease (NAFLD) are not well defined. We investigated the association of gallstones and cholecystectomy with NAFLD in a large, national, population-based study.METHODS: Among adult participants in the third US National Health and Nutrition Examination Survey, 1988-1994, ultrasonography for gallstone disease was performed, and videotapes were subsequently evaluated for NAFLD. Odds ratios (ORs) for the association of gallstone disease with NAFLD were calculated using logistic regression analysis to adjust for common associated factors.RESULTS: Among 12,232 participants without viral hepatitis or significant alcohol intake, the prevalence of gallstones was 7.4%, cholecystectomy 5.6%, and NAFLD 20.0%. Participants with cholecystectomy had higher age-sex-adjusted prevalence of NAFLD (48.4%) than those with gallstones (34.4%) or without gallstone disease (17.9%) (P