Human infection with an avian H9N2 influenza A virus in Hong Kong in 2003
Human infection with an avian H9N2 influenza A virus in Hong Kong in 2003
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DOI：
10.1128/jcm.43.11.5760-5767.2005
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发表时间：
2005-11-01
影响因子：
9.4
通讯作者：
Guan, Y
中科院分区：
文献类型：
--
作者：
Butt, KM;Smith, GJD;Guan, Y
自1998年以来，禽流感病毒H9 N2 A在亚洲多次引起人类感染。在这里，我们报告了2003年香港一名5岁儿童感染H9 N2流感病毒的情况。为确定可能的感染来源，我们对2003年1月至10月从香港家禽市场分离出的人类分离株和其他H9 N2流感病毒进行了基因和抗原鉴定。研究结果显示，人类H9 N2流感病毒（A/Hong Kong/2108/03）纯粹源自禽鸟，并与一些在本港街市家禽间流传的病毒有密切关系。H9 N2流感病毒在中国南方家禽市场的持续存在增加了禽-人种间传播的可能性。
Avian H9N2 influenza A virus has caused repeated human infections in Asia since 1998. Here we report that an H9N2 influenza virus infected a 5-year-old child in Hong Kong in 2003. To identify the possible source of the infection, the human isolate and other H9N2 influenza viruses isolated from Hong Kong poultry markets from January to October 2003 were genetically and antigenically characterized. The findings of this study show that the human H9N2 influenza virus, A/Hong Kong/2108/03, is of purely avian origin and is closely related to some viruses circulating in poultry in the markets of Hong Kong. The continued presence of H9N2 influenza viruses in poultry markets in southern China increases the likelihood of avian-to-human interspecies transmission.