Serotonin transporter gene polymorphism and antidepressant response
Serotonin transporter gene polymorphism and antidepressant response
复制标题
DOI：
10.1097/00001756-200001170-00042
复制
发表时间：
2000-01-17
期刊：
影响因子：
1.7
通讯作者：
Carroll, BJ
中科院分区：
文献类型：
--
作者：
Kim, DK;Lim, SW;Carroll, BJ
我们检测了5-羟色胺转运体（5-HTT）基因的等位基因多态性和对6周选择性5-羟色胺再摄取抑制剂（SSRI）药物氟西汀或帕罗西汀治疗的抗抑郁反应。我们对120名患者和252名正常对照进行了基因分型，使用聚合酶链反应对5-HTT基因的第二内含子和启动子区域进行了基因组DNA扩增。抑郁症的诊断与5-HTT多态性无关。内含子2纯合子1/1或启动子区纯合子SIS患者的疗效优于其他患者（p
We examined allelic polymorphisms of the serotonin transporter (5-HTT) gene and antidepressant response to 6 weeks' treatment with the selective serotonin reuptake inhibitor (SSRI) drugs fluoxetine or paroxetine. We genotyped 120 patients and 252 normal controls, using polymerase chain reaction of genomic DNA with primers flanking the second intron and promoter regions of the 5-HTT gene. Diagnosis of depression was not associated with 5-HTT polymorphisms. Patients homozygous 1/1 in intron2 or homozygous sis in the promoter region showed better responses than all others (p