The small heat shock proteins family: The long forgotten chaperones
The small heat shock proteins family: The long forgotten chaperones
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DOI：
10.1016/j.biocel.2012.02.022
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发表时间：
2012-10-01
影响因子：
4
通讯作者：
Kampinga, H. H.
中科院分区：
文献类型：
--
作者：
Garrido, C.;Paul, C.;Kampinga, H. H.
小分子热休克蛋白是一类非ATP依赖的分子伴侣，其中一些分子已被证明可以阻止蛋白质聚集并帮助细胞在应激条件下生存。虽然比HSP 70/HSPA或HSP 90/HSPC等高分子量热休克蛋白的研究少得多，但它们在生理病理过程和人类疾病中的意义现在得到了很好的证明，因为它将在这个特殊问题的不同评论中进行讨论。在这篇文章中，我们将对小分子热休克蛋白家族做一个简单的介绍。这篇文章是一个定向问题的一部分，题为：小HSP在生理学和病理学。(C)2012爱思唯尔有限公司出版
Small heat shock proteins are a rather heterogeneous family of ATP-independent chaperones, some of which have been proven to block protein aggregation and help the cells to survive stressful conditions. Although much less studied than high molecular weight HSPs like HSP70/HSPA or HSP90/HSPC, their implication in physio-pathological processes and human diseases is now well evidenced, as it will be discussed in the different reviews of this special issue. In this mini-review we will just present a general introduction about the small heat shock proteins family. This article is part of a Directed Issue entitled: Small HSPs in physiology and pathology. (C) 2012 Published by Elsevier Ltd.