Significant Relationship of Visual Field Sensitivity in Central 10° to Thickness of Retinal Layers in Retinitis Pigmentosa.
Significant Relationship of Visual Field Sensitivity in Central 10° to Thickness of Retinal Layers in Retinitis Pigmentosa.
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色素性视网膜炎中中央 10° 视野灵敏度与视网膜层厚度的显着关系。
DOI：
10.1167/iovs.18-24635
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Terasaki H.
中科院分区：
文献类型：
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作者：
Sayo A;Ueno S;Kominami T;Okado S;Inooka D;Komori S;Terasaki H.
目的：探讨色素性视网膜炎（RP）患者视网膜中央10区敏感度与视网膜层厚度的关系。方法：对52例RP患者进行研究。所有患者均采用Humphrey Field Analyzer 10-2程序（HFA10-2）和光谱域光学相干断层扫描（SD-OCT）进行检查。在距中央窝1、3、5、7、9处测量感光器外段（OS）、外核层（ONL）、内核层（INL）和视网膜神经纤维层（RNFL）的厚度。对40名健康受试者的SD-OCT图像进行了相同的测量，并作为对照。测定视网膜敏感度与视网膜层厚度之间的关系。结果：OS、ONL及其产物的厚度与视网膜敏感度呈显著正相关。INL厚度与灵敏度呈显著负相关。与敏感性相关性最强的是OS厚度（边际r2 [mR 2]= 0.525， P< 0.001），其次是OS与ONL厚度的乘积（mR 2= 0.420， P< 0.001）、ONL厚度（mR 2= 0.416， P< 0.001）和INL厚度（mR 2= 0.014， P= 0.044）。RNFL厚度与敏感性无相关性（mr2 = 0.005， P= 0.331）。结论：与以往报道相比，OS厚度比OS和ONL的乘积更能反映视网膜敏感性。
Purpose: To determine the relationship between the sensitivity of the retina in the central 10 and the thickness of the retinal layers in patients with retinitis pigmentosa (RP).Methods: Fifty-two RP patients were studied. All of the patients had been examined by the Humphrey Field Analyzer 10-2 program (HFA10-2) and spectral-domain optical coherence tomography (SD-OCT). The thicknesses of the photoreceptor outer segment (OS), outer nuclear layer (ONL), inner nuclear layer (INL), and the retinal nerve fiber layer (RNFL) were measured at 1, 3, 5, 7, and 9 from the fovea. The same measurements were made on the SD-OCT images of 40 healthy subjects and used as controls. The relationships between the retinal sensitivities and retinal layer thicknesses were determined.Results: The thicknesses of the OS and ONL and their product were significantly and positively correlated with the retinal sensitivities. The thickness of the INL was significantly and negatively correlated with the sensitivity. The strongest correlation with the sensitivity was with the OS thickness (marginal R 2 [mR 2]= 0.525, P< 0.001), followed by the product of the OS and ONL thicknesses (mR 2= 0.420, P< 0.001), ONL thickness (mR 2= 0.416, P< 0.001), and the INL thickness (mR 2= 0.014, P= 0.044). The thickness of the RNFL was not correlated with the sensitivity (mR 2= 0.005, P= 0.331).Conclusions: In contrast to previous reports, the thickness of the OS reflected the retinal sensitivity better than the product of OS and ONL.