AGGRESSIVE-BEHAVIOR AND ALTERED AMOUNTS OF BRAIN-SEROTONIN AND NOREPINEPHRINE IN MICE LACKING MAOA
AGGRESSIVE-BEHAVIOR AND ALTERED AMOUNTS OF BRAIN-SEROTONIN AND NOREPINEPHRINE IN MICE LACKING MAOA
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DOI：
10.1126/science.7792602
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发表时间：
1995-06-23
期刊：
影响因子：
56.9
通讯作者：
DEMAEYER, E
中科院分区：
文献类型：
--
作者：
CASES, O;SEIF, I;DEMAEYER, E
单胺氧化酶A(MAOA)是一种降解5-羟色胺和去甲肾上腺素的酶，最近被证明与一个荷兰家庭的男性的攻击行为有关。分离到一株转基因小鼠，其中转基因整合导致MAOA编码基因的缺失，提供了MAOA缺乏症的动物模型，在仔鼠脑中，5-羟色胺浓度增加了9倍，并存在5-羟色胺样免疫反应。在儿茶酚胺能神经元中，在幼鼠和成年脑中，去甲肾上腺素的浓度增加了一倍，并且在躯体感觉皮质观察到了细胞构筑的变化。幼崽的行为变化，包括颤抖、站立困难和恐惧，可以被5-羟色胺合成抑制剂对氯苯丙氨酸逆转。成年人表现出明显的行为综合症，包括男性攻击性增强。
Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family. A line of transgenic mice was isolated in which transgene integration caused a deletion in the gene encoding MAOA, providing an animal model of MAOA deficiency, in pup brains, serotonin concentrations were increased up to ninefold, and serotonin-like immunoreactivity was present. in catecholaminergic neurons, In pup and adult brains, norepinephrine concentrations were increased up to twofold, and I cytoarchitectural changes were observed in the somatosensory cortex. Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine. Adults manifested a distinct behavioral syndrome, including enhanced aggression in males.