From a common progenitor to distinct liver epithelial phenotypes.
From a common progenitor to distinct liver epithelial phenotypes.
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DOI：
10.1016/j.ceb.2018.02.008
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发表时间：
2018-10
影响因子：
7.5
通讯作者：
Müsch A
中科院分区：
文献类型：
--
作者：
Müsch A
脊椎动物的肝脏是一个迷人的案例研究如何优化细胞形式的功能。为了执行其职责，肝脏组装两种不同的管腔形成上皮表型：1）在肝细胞（胆小管）之间形成具有分支的毛细血管样管腔网络的索;和2）由围绕中心腔排列并连接到胆小管的胆管上皮细胞形成的小管。这些显著不同的上皮极性表型是如何产生并连接成一个连续的管腔网络是主要的未解决的问题。最近的研究已经表征了来自共同祖细胞的两种上皮谱系的分歧，描述了在胆管树形态发生期间胆小管形成与胆管分支的协调，并涉及RhoA依赖性E-钙粘蛋白粘附在决定肝细胞或胆管表型的分化中。
The vertebrate liver presents a fascinating case study for how cell form is optimized for function. To execute its duties the liver assembles two distinct lumen-forming epithelial phenotypes: 1) cords with a branched, capillary-like luminal network formed between hepatocytes (bile canaliculi); and 2) tubular ducts formed by biliary epithelial cells arranged around a central cavity and connected to the bile canaliculi. How these remarkably different epithelial polarity phenotypes are generated and joined into a contiguous luminal network are major unresolved questions. Recent studies have characterized the divergence of the two epithelial lineages from common progenitors, described the coordination of bile canaliculi formation with bile duct branching during biliary tree morphogenesis and implicated RhoA-dependent E-cadherin adhesion in the decision to polarize with hepatocytic or biliary phenotype.
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影响因子：
4.4
作者：
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通讯作者：
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影响因子：
4
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通讯作者：
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影响因子：
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