Seroprevalence of Helicobacter pylori infection and gastric mucosal atrophy in Bhutan, a country with a high prevalence of gastric cancer
Seroprevalence of Helicobacter pylori infection and gastric mucosal atrophy in Bhutan, a country with a high prevalence of gastric cancer
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DOI：
10.1099/jmm.0.060905-0
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发表时间：
2013-10-01
影响因子：
3
通讯作者：
Yamaoka, Yoshio
中科院分区：
文献类型：
--
作者：
Shiota, Seiji;Mahachai, Varocha;Yamaoka, Yoshio
胃癌是世界上癌症相关死亡的第二大原因。近年来，血清幽门螺杆菌抗体和胃蛋白酶原（PG）已被用于胃癌筛查。据报道，与邻国相比，不丹的胃癌发病率相当高。在这项研究中，来自不丹三个地区的381名受试者进行了胃粘膜萎缩和血清学参数的评估。Anti-H。采用ELISA法检测幽门螺杆菌IgG、PG I、PG II及细胞毒素相关基因A （CagA）抗体。根据幽门螺杆菌和PG血清阳性情况将受试者分为A组（幽门螺杆菌阴性/PG阴性）、B组（幽门螺杆菌阳性/PG阴性）、C组（幽门螺杆菌阳性/PG阳性）和D组（幽门螺杆菌阴性/PG阳性）。381例调查对象幽门螺杆菌感染率为71.1%(271/381)，农村感染率较高。PG I/II比值与上颌窦和椎体萎缩评分呈显著负相关(P
Gastric cancer is the second leading cause of cancer-related mortality in the world. Recently, serum Helicobacter pylori antibodies and pepsinogen (PG) have been used for gastric cancer screening. The incidence of gastric cancer in Bhutan is reported to be quite high compared with that in neighbouring countries. In this study, 381 subjects from three areas of Bhutan were assessed for gastric mucosal atrophy and serological parameters. Anti-H. pylori IgG, PG I, PG II and cytotoxin-associated gene A (CagA) antibodies were measured using ELISA. Subjects were classified into four groups according to H. pylori and PG seropositivity: Group A (H. pylori-negative/PG-negative), Group B (H. pylori-positive/PG-negative), Group C (H. pylori-positive/PG-positive) and Group D (H. pylori-negative/PG-positive). The prevalence of H. pylori in the 381 subjects was 71.1 % (271/381), with high infection rates found in rural areas. The PG I/II ratio was significantly inversely correlated with the atrophy score in the antrum and the corpus (P