INTERLEUKIN-1
INTERLEUKIN-1
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DOI：
10.1111/j.1749-6632.1988.tb21627.x
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发表时间：
1988-12-30
影响因子：
5.2
通讯作者：
DINARELLO, CA
中科院分区：
文献类型：
--
作者：
DINARELLO, CA
IL-1 是多种细胞的多肽产物，介导对感染和损伤的急性期反应的多个组成部分。其最引人注目的生物学特性是能够在多种细胞中诱导花生四烯酸代谢，包括大脑中的 PGE、成纤维细胞、滑膜细胞和软骨细胞；此外，IL-1在淋巴细胞和其他细胞中诱导脂氧合酶产物。 IL-1已被克隆。有两种形式。来自人类单核细胞的 IL-1 的主要形式的 pI 为 7（也称为 beta），最初作为前体分子 (31 kD) 合成。还存在次要形式（小于 100 倍）（pI 5，也称为 alpha）。 IL-1 在淋巴因子和单核因子中似乎是独特的，因为它没有用于裂解的信号肽序列。根据刺激的不同，细胞内前体 IL-1 的水平可能很高，而某些细胞激活剂会产生大量经过加工的 IL-1。前体 IL-1 被切割成 17.5 kD 肽，这是主要的细胞外形式。 IL-1 诱导前列腺素和淋巴细胞活化以及许多不同的生物活性。这些影响包括发烧、PGE 产生、滑膜细胞和软骨细胞释放蛋白酶、骨吸收、急性期蛋白质合成和其他影响。尽管很少有研究显示 IL-1 对胃肠道的影响，但 IL-1 的多种生物学特性表明 IL-1 在炎症性肠病以及介导全身急性期反应中观察到的一些胃肠道变化中发挥作用。
IL-1 is a polypeptide product of various cells that mediates several components of the acute-phase response to infection and injury. Its most dramatic biological property is its ability to induce arachidonate metabolites in a variety of cells including PGE in the brain, fibroblasts, synovial cells, and chrondrocytes; in addition, IL-1 induces lipoxygenase products in lymphocytes and other cells. IL-1 has been cloned. There are two forms. The predominant form of IL-1 from human monocytes has a pI of 7 (also called beta) and is initially synthesized as a precursor molecule (31 kD). A minor form (less than 100-fold) also exists (pI 5, also called alpha). IL-1 seems unique among the lymphokines and monokines in that there is no signal peptide sequence for cleavage. Depending on the stimulus, intracellular levels of precursor IL-1 can be high, whereas some cell activators result in large amounts of processed IL-1. Precursor IL-1 is cleaved into a 17.5-kD peptide, which is the predominant extracellular form. IL-1 induces prostaglandins and lymphocyte activation as well as many different biological activities. These include fever, PGE production, protease release from synovial cells and chondrocytes, bone resorption, acute-phase protein synthesis, and other effects. Although there are few studies showing an IL-1 effect on the gastrointestinal tract, the multiple biological properties of IL-1 suggest that IL-1 plays a role in inflammatory bowel disease as well as in mediating some of the gastrointestinal changes observed in systemic acute-phase responses.