Role of nitric oxide in rat locus coeruleus in hypoxia-induced hyperventilation and hypothermia
Role of nitric oxide in rat locus coeruleus in hypoxia-induced hyperventilation and hypothermia
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DOI：
10.1097/00001756-200009110-00033
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发表时间：
2000-09-11
期刊：
影响因子：
1.7
通讯作者：
Branco, LGS
中科院分区：
文献类型：
--
作者：
Fabris, G;Steiner, AA;Branco, LGS
蓝斑调节对缺氧的通气和体温调节反应，并含有一氧化氮合酶。因此，我们研究了单侧蓝斑显微注射 L-NAME 对缺氧过度通气和体温过低的影响。在将L-NAME（100nmol/0.5μl）显微注射到蓝斑之前和之后测量通气量和体温，然后进行缺氧。对照大鼠接受显微注射 D-NAME（L-NAME 的无活性对映体）。在含氧量正常的情况下，L-NAME 治疗不会影响通气或体温。 D-NAME 不会影响缺氧引起的过度换气和体温过低。 L-NAME 治疗降低了对缺氧的通气反应，但不影响缺氧引起的体温过低。这些数据表明，蓝斑中的一氧化氮参与缺氧的通气反应，对蓝斑神经元进行抑制性调节，但在缺氧引起的体温过低中不起任何作用。 NeuroReport 11：2991-2995 (C) 2000 Lippincott Williams & Wilkins。
The locus coeruleus modulates the ventilatory and thermoregulatory response to hypoxia and contains nitric oxide synthase. Therefore, we examined the effects of L-NAME unilaterally microinjected into the locus coeruleus on hypoxic hyperventilation and hypothermia. Ventilation and body temperature were measured before and after microinjection of L-NAME (100 nmol/0.5 mu l) into the locus coeruleus, followed by hypoxia. Control rats received microinjection of D-NAME (an inactive enantiomer of L-NAME). Under normoxia, L-NAME treatment did not affect ventilation or body temperature. D-NAME did not affect hypoxia-induced hyperventilation and hypothermia. L-NAME treatment reduced the ventilatory response to hypoxia but did not affect hypoxia-induced hypothermia. These data suggest that nitric oxide in the locus coeruleus is involved in the ventilatory response to hypoxia, exercising an inhibitory modulation on the locus coeruleus neurons, but plays no role in hypoxia-induced hypothermia. NeuroReport 11:2991-2995 (C) 2000 Lippincott Williams & Wilkins.