Discrepant findings in immune responses to JC virus in patients receiving natalizumab.
Discrepant findings in immune responses to JC virus in patients receiving natalizumab.
复制标题
接受那他珠单抗治疗的患者对 JC 病毒的免疫反应存在差异。
DOI：
10.1016/s1474-4422(10)70124-1
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Koralnik,IgorJ
中科院分区：
文献类型：
--
作者：
Tan,ChenS;Chen,Yiping;Viscidi,RaphaelP;Kinkel,RPhilip;Stein,MarionC;Koralnik,IgorJ
We read with interest both the paper by Jilek and colleagues, 1 which describes immunological and virological findings in a cohort of patients with multiple sclerosis before and during the course of natalizumab therapy, and the associated commentary2 comparing their results with our recent study of similar design. 3 Whereas we found a decrease in the magnitude of the cellular immune response against JC virus in natalizumab-treated patients, and an increased incidence of JC virus in the urine and blood, Jilek and colleagues1 found an increase in cellular immune responses to JC virus, Epstein-Barr virus and cytomegalovirus, stable incidence of JC virus in the urine, and no JC virus in the blood. We have difficulties integrating the humoral and cellular immune response data presented by Jilek and colleagues. 3 They reported that only 12 of 24 patients treated with natalizumab and six of 14 treated with interferon beta had antibodies against JC virus, and one additional JC virus-seronegative patient in the natalizumab group had detectable JC virus in the urine. None of the patients seroconverted for JC virus during the study. Based on these data, the 11 of 24 patients treated with natalizumab and eight of 14 treated with interferon beta who had negative JC virus serology might not have been exposed to JC virus, and therefore would not be expected to have a cellular immune response to this virus. The inclusion of JC virus-seronegative patients along with the seropositive patients might have altered the final analysis of cellular immune responses. Similarly, serological assays for Epstein Barr virus and cytomegalovirus should have been done and only seropositive
