Lack of neutralizing antibody response to HIV-1 predisposes to superinfection
Lack of neutralizing antibody response to HIV-1 predisposes to superinfection
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DOI：
10.1016/j.virol.2006.08.009
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发表时间：
2006-11-10
期刊：
影响因子：
3.7
通讯作者：
Richman, Douglas D.
中科院分区：
文献类型：
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作者：
Smith, Davey M.;Strain, Matthew C.;Richman, Douglas D.
HIV-1 重复感染的发生为研究免疫保护的相关性提供了独特的机会。在这里，我们描述了一组最近感染的、接受 HIV 重复感染筛查的个体的中和抗体反应。与非重复感染病例对照相比，三名被鉴定为 HIV 重复感染的个体的交叉保护性和自体中和抗体反应较少。中和抗体可能对于防止重复感染至关重要，并且可以解释为什么仅在最近感染或治疗中断后才记录到重复感染。这些数据对疫苗开发具有相当大的影响。由爱思唯尔公司出版
Occurrences of HIV-1 superinfection offer a unique opportunity to investigate the correlates of immune protection. Here we describe the neutralizing antibody responses of a cohort of recently infected individuals who were screened for HIV superinfection. Three individuals identified with HIV superinfection had less cross-protective and autologous neutralizing antibody response than their non-superinfected casecontrols. Neutralizing antibody may be crucial in the protection against superinfection and may explain why superinfection has only been documented following recent infection or treatment interruption. These data have considerable implications for vaccine development. Published by Elsevier Inc.