A constitutive promoter directs expression of the nerve growth factor receptor gene.
A constitutive promoter directs expression of the nerve growth factor receptor gene.
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组成型启动子指导神经生长因子受体基因的表达。
DOI：
10.1128/mcb.8.8.3160-3167.1988
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发表时间：
1988
影响因子：
5.3
通讯作者：
Chao,M
中科院分区：
文献类型：
--
作者：
Sehgal,A;Patil,N;Chao,M
神经生长因子受体的表达通常限于以发育调节方式源自神经嵴的细胞。我们分析了人类神经生长因子受体基因的启动子序列，发现该受体启动子类似于与具有管家和生长相关功能的组成型表达基因相关的其他启动子。与这些其他基因不同，转录起始发生在一个主要位点而不是多个位点。神经生长因子受体启动子的组成性质可能解释了该基因在基因转移后在多种异源细胞中转录的能力。受体基因的内含子-外显子结构表明结构特征被精确地划分为离散的结构域。
Expression of nerve growth factor receptor is normally restricted to cells derived from the neural crest in a developmentally regulated manner. We analyzed promoter sequences for the human nerve growth factor receptor gene and found that the receptor promoter resembles others which are associated with constitutively expressed genes that have housekeeping and growth-related functions. Unlike these other genes, the initiation of transcription occurred at one major site rather than at multiple sites. The constitutive nature of the nerve growth factor receptor promoter may account for the ability of this gene to be transcribed in a diverse number of heterologous cells after gene transfer. The intron-exon structure of the receptor gene indicated that structural features are precisely divided into discrete domains.