Evaluation of delayed-image bone scintigraphy to assess bone formation after distraction osteogenesis in dogs.
Evaluation of delayed-image bone scintigraphy to assess bone formation after distraction osteogenesis in dogs.
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DOI：
10.2460/ajvr.67.5.790
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发表时间：
2006-05
影响因子：
1
通讯作者：
L. Theyse;H. Hazewinkel;M. Terlou;Y. Pollak;G. Voorhout
中科院分区：
文献类型：
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作者：
L. Theyse;H. Hazewinkel;M. Terlou;Y. Pollak;G. Voorhout
目的应用延迟成像骨密度成像技术定量评价牵张延长犬小腿模型的成骨情况。动物12只成年拉布拉多寻回犬。程序将犬随机分配至3组中的1组。在每只犬的右前肢上安装圆形外固定系统。在第1组和第2组中对胫骨和腓骨远端部分进行截骨术，然后仅在第1组中进行10 mm的延长手术。第三组为假手术对照组。术后2、4、6周分别行锝-99m羟基亚甲基二膦酸盐延迟显像骨密度扫描。计算延迟图像与感兴趣区域、延迟图像与下肢和延迟图像与股动脉造影活动比率。通过使用光密度图像分析定量新骨形成，并比较骨密度比值。结果：在牵引组和截骨组，延迟图像与感兴趣区域和延迟图像与下肢的比率显著增加。尽管光密度图像分析显示牵引后骨形成增加，但两组的感兴趣区域比率和下肢比率相似。所有犬的延迟图像-股骨比均增加。结论和临床相关性延迟影像骨密度比值不能有效区分牵引诱导骨量和截骨诱导骨量。由于环形外固定支架的放置，邻近股骨的代谢性骨活动增加。延迟成像骨密度成像对定量监测骨形成的敏感性不足，但可作为骨愈合的早期预测指标。
OBJECTIVE To quantitatively assess distraction-induced bone formation in a crural lengthening model in dogs by use of delayed-image bone scintigraphy. ANIMALS 12 mature Labrador Retrievers. PROCEDURE Dogs were randomly allocated to 1 of 3 groups. A circular external skeletal fixation system was mounted on the right crus of each dog. Osteotomy of the distal portion of the tibia and fibula was performed in groups 1 and 2 and was followed by a lengthening procedure of 10 mm in the first group only. The third group served as sham-operated controls. Delayed-image bone scintigraphy with technetium-99m hydroxy methylene diphosphonate was performed 2, 4, and 6 weeks after surgery. Delayed-image-to-region-of-interest, delayed-image-to-crural, and delayed-image-to-femoral scintigraphic activity ratios were calculated. New bone formation was quantified by use of densitometric image analysis, and values for the scintigraphic ratios were compared. RESULTS In the distraction and osteotomy groups, delayed-image-to-region-of-interest and delayed-image-to-crural ratios increased significantly. Although densitometric image analysis revealed increased bone formation after distraction, the region-of-interest ratios and crural ratios were similar in both groups. All dogs had increased delayed-image-to-femoral ratios. CONCLUSIONS AND CLINICAL RELEVANCE Delayed-image bone scintigraphy ratios were not effective at differentiating between the amounts of distraction-induced bone and osteotomy-induced bone. Metabolic bone activity in the adjacent femur was increased as a consequence of circular external skeletal fixator placement. Delayed-image bone scintigraphy was not adequately sensitive to quantitatively monitor bone formation but may be useful as an early predictor of bone healing.