TRP Channels: Pain enters through the side door.

TRP Channels: Pain enters through the side door.
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TRP通道:疼痛从侧门进入。

DOI:
10.1038/nchembio.1470
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发表时间:
2014
影响因子:
14.8
通讯作者:
Liman,EmilyR
Liman,EmilyR
中科院分区:
生物学1区
文献类型:
--
作者:
Liman,EmilyR

文献摘要

相似文献

TRPM3 可以通过两个不同的孔渗透离子:中心孔和可能的替代“欧米茄孔”。离子通过 TRPM3 的替代孔进入有助于产生疼痛,使其成为新型镇痛药设计的有吸引力的目标。
TRPM3 can permeate ions through two distinct pores—the central pore and a likely alternative 'omega pore'. Entry of ions through the alternative pore of TRPM3 contributes to pain generation, making it an attractive target for the design of new analgesics.