THE RELATIONSHIP BETWEEN PERINATAL HYPOXIA AND NEWBORN ENCEPHALOPATHY
THE RELATIONSHIP BETWEEN PERINATAL HYPOXIA AND NEWBORN ENCEPHALOPATHY
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DOI：
10.1016/s0002-9378(85)80205-2
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发表时间：
1985-01-01
影响因子：
9.8
通讯作者：
KARCHMAR, EJ
中科院分区：
文献类型：
--
作者：
LOW, JA;GALBRAITH, RS;KARCHMAR, EJ
在 303 名选定的高危早产儿和足月新生儿中，30% 的人观察到新生儿脑病。 65 例新生儿脑病为轻度或中度，27 例为重度。新生儿脑病对 1 岁时运动和认知缺陷的预测意义从无脑病儿童 (17%)、轻度或中度脑病儿童 (25%) 和重度脑病儿童 (55%) 的缺陷发生率中可见一斑。与新生儿脑病显着相关的生物学危险因素包括严重的产时胎儿缺氧、中度和重度新生儿呼吸道并发症和严重感染。围产期缺氧与 26% 的轻度和中度新生儿脑病病例以及 66% 的重度新生儿脑病病例有关，并可能是其原因之一。在轻度和中度脑病病例中，胎儿和新生儿缺氧的发生率相同；然而，在严重新生儿脑病的情况下，新生儿缺氧的频率是胎儿缺氧的两倍。
Newborn encephalopathy was observed in 30% of 303 selected high-risk preterm and term newborn infants. The newborn encephalopathy was mild or moderate in 65 children and severe in 27. The predictive significance of newborn encephalopathy to motor and cognitive deficits at 1 yr was evident from the incidence of deficits in the children with no encephalopathy (17%), in children with mild or moderate encephalopathy (25%) and in children with severe encephalopathy (55%). The biologic risk factors with a significant association with newborn encephalopathy included severe intrapartum fetal hypoxia, moderate and severe newborn respiratory complications and major infections. Perinatal hypoxia was associated with, and may have contributed to, 26% of the cases of mild and moderate newborn encephalopathy and 66% of the cases of severe newborn encephalopathy. Fetal and newborn hypoxia occurred with equal frequencies in cases of mild and moderate encephalopathy; however, newborn hypoxia was twice as frequent as fetal hypoxia in cases of severe newborn encephalopathy.