High expression of macrophage colony-stimulating factor in peritumoral liver tissue is associated with poor survival after curative resection of hepatocellular carcinoma
High expression of macrophage colony-stimulating factor in peritumoral liver tissue is associated with poor survival after curative resection of hepatocellular carcinoma
复制标题
瘤周肝组织中巨噬细胞集落刺激因子的高表达与肝细胞癌根治性切除后生存率低相关
DOI：
10.1200/jco.2007.15.6521
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发表时间：
2008-06-01
影响因子：
45.3
通讯作者：
Sun, Hui-Chuan
中科院分区：
文献类型：
--
作者：
Zhu, Xiao-Dong;Zhang, Ju-Bo;Sun, Hui-Chuan
目的探讨巨噬细胞集落刺激因子（M-CSF）在肝细胞癌（HCC）根治性切除后瘤内及瘤周表达的价值。采用免疫组化方法，对105例经肝切除术的肝癌患者的配对肿瘤和瘤周肝组织进行组织微阵列检测M- csf的表达和巨噬细胞（M Phi）的密度。评估这些及其他临床病理因素的预后价值。结果瘤内M- csf和M- Phi浓度均与总生存期（OS）或无病生存期（DFS）无关。肿瘤周围高M- csf和M- Phi密度与肿瘤大、肝内转移和TNM分期相关，是OS （P = 0.001和P = 0.001）和DFS （P = 0.001和P = 0.003）的独立预后因素，并影响早期复发率。在一小部分HCC亚群中，瘤周M-CSF也与OS和DFS相关（分别为P = 0.038和P = 0.001）。联合瘤周M- csf和M- Phi预测患者死亡和疾病复发的能力较好（两者P = 0.001）。结论高瘤周M- csf和M- Phi与HCC进展、疾病复发和肝切除术后生存率差相关，突出了瘤周组织在HCC复发转移中的重要性。M- csf和M- Phi可能是术后辅助治疗的目标。
PurposeTo investigate prognostic values of the intratumoral and peritumoral expression of macrophage colony-stimulating factors (M-CSF) in hepatocellular carcinoma (HCC) patients after curative resection.Patients and MethodsExpression of M-CSF and density of macrophages ( M Phi) were assessed by immunohistochemistry in tissue microarrays containing paired tumor and peritumoral liver tissue from 105 patients who had undergone hepatectomy for histologically proven HCC. Prognostic value of these and other clinicopathologic factors was evaluated.ResultsNeither intratumoral M-CSF nor M Phi density was associated with overall survival ( OS) or disease-free survival (DFS). High peritumoral M-CSF and M Phi density, which correlated with large tumor size, presence of intrahepatic metastasis, and high TNM stage, were independent prognostic factors for both OS ( P =.001 and P =.001, respectively) and DFS ( P =.001 and P =.003, respectively) and affected incidence of early recurrence. In a small HCC subset, peritumoral M-CSF was also correlated with both OS and DFS ( P =.038 and P =.001, respectively). The combination of peritumoral M-CSF and M Phi had a better power to predict the patients' death and disease recurrence ( P =.001 for both).ConclusionHigh peritumoral M-CSF and M Phi were associated with HCC progression, disease recurrence, and poor survival after hepatectomy, highlighting the importance of peritumoral tissue in the recurrence and metastasis of HCC. M-CSF and M Phi may be targets of postoperative adjuvant therapy.