ADJUSTMENT FORMULAS FOR MATERNAL SERUM ALPHA-FETOPROTEIN, HUMAN CHORIONIC-GONADOTROPIN, AND UNCONJUGATED ESTRIOL TO MATERNAL WEIGHT AND SMOKING
ADJUSTMENT FORMULAS FOR MATERNAL SERUM ALPHA-FETOPROTEIN, HUMAN CHORIONIC-GONADOTROPIN, AND UNCONJUGATED ESTRIOL TO MATERNAL WEIGHT AND SMOKING
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DOI：
10.1002/pd.1970130207
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发表时间：
1993-02-01
影响因子：
3
通讯作者：
CAESAR, J
中科院分区：
文献类型：
--
作者：
BARTELS, I;HOPPESIEVERT, B;CAESAR, J
对4131例非吸烟和1018例吸烟妇女孕中期血清甲胎蛋白（AFP）、人绒毛膜促性腺激素（hCG）和未结合雌三醇（uE 3）水平进行了检测。所有三种分析物的水平随着体重的增加而降低。吸烟者的AFP中位数显着增加，呈剂量反应相关;吸烟者的hCG下降21%，uE 3下降3%，呈非剂量相关。在唐氏综合征的风险估计中，应考虑回归函数用于调整血清水平的体重和吸烟，以便更准确地给出女性的个体风险。
Serum levels of alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), and unconjugated oestriol (uE3) were measured in serum samples of 4131 non-smoking and 1018 smoking women during the second trimester of pregnancy. The levels of all three analytes decreased with increasing body weight. The AFP median was significantly increased in smokers in a dose-response association; hCG decreased by 21 per cent and uE3 decreased by 3 per cent in smokers in a non-dose-related fashion. Regression functions for adjustment of serum levels for weight and smoking should be considered in risk estimation for Down syndrome in order to give a woman's individual risk more precisely.