Enhanced High-Rate Shockwave Lithotripsy Stone Comminution in an In Vivo Porcine Model Using Acoustic Bubble Coalescence.
Enhanced High-Rate Shockwave Lithotripsy Stone Comminution in an In Vivo Porcine Model Using Acoustic Bubble Coalescence.
复制标题
使用声学气泡聚结增强体内猪模型中的高速冲击波碎石碎石。
DOI：
10.1089/end.2016.0407
复制
发表时间：
2016
影响因子：
2.7
通讯作者：
Hall,TimothyL
中科院分区：
文献类型：
--
作者：
AlaviTamaddoni,Hedieh;Roberts,WilliamW;Duryea,AlexanderP;Cain,CharlesA;Hall,TimothyL
空化对于冲击波碎石术 (SWL) 期间碎石的功效起着重要作用。尽管泌尿系结石表面的空化有助于改善破碎，但传播路径上的空化气泡可能会屏蔽或阻止后续的冲击波 (SW)，并可能引起附带的组织损伤。先前的体外研究表明，在每次 SWL 后应用低振幅声波可以迫使气泡巩固并增强 SWL 功效。在这项研究中，测试了在体内应用声学气泡聚结（ABC）的可行性。模型结石经皮植入并用 2500 次碎石 SW 以 120 SW/分钟进行治疗，有或没有 ABC。比较结石粉碎的结果，使用 ABC 时，结石粉碎过程得到显着改善。如果没有 ABC，只有 25% 的石头质量会破碎成尺寸 <2 毫米的颗粒。使用 ABC，75% 的质量被破碎成尺寸 <2mm 的颗粒。这些结果表明 ABC 可以减少残留气泡核的屏蔽效应，从而实现更有效的 SWL 处理。
Cavitation plays a significant role in the efficacy of stone comminution during shockwave lithotripsy (SWL). Although cavitation on the surface of urinary stones helps to improve fragmentation, cavitation bubbles along the propagation path may shield or block subsequent shockwaves (SWs) and potentially induce collateral tissue damage. Previousin vitrowork has shown that applying low-amplitude acoustic waves after each SW can force bubbles to consolidate and enhance SWL efficacy. In this study, the feasibility of applying acoustic bubble coalescence (ABC)in vivowas tested. Model stones were percutaneously implanted and treated with 2500 lithotripsy SWs at 120 SW/minute with or without ABC. Comparing the results of stone comminution, a significant improvement was observed in the stone fragmentation process when ABC was used. Without ABC, only 25% of the mass of the stone was fragmented to particles <2 mm in size. With ABC, 75% of the mass was fragmented to particles <2 mm in size. These results suggest that ABC can reduce the shielding effect of residual bubble nuclei, resulting in a more efficient SWL treatment.