Dynamic Covalent Single-Chain Polymer Nanoparticles
Dynamic Covalent Single-Chain Polymer Nanoparticles
复制标题
DOI：
10.1021/ma201331f
复制
发表时间：
2011-09-27
期刊：
影响因子：
5.5
通讯作者：
Fulton, David A.
中科院分区：
文献类型：
--
作者：
Murray, Benjamin S.;Fulton, David A.
聚合物纳米颗粒是通过形成动态共价键驱动线型聚合物的链塌缩而制备的。聚（乙烯基苯甲醛）的线性链通过与双酰肼交联剂形成动态共价酰腙键进行分子内交联。交联密度被证明是由所使用的交联剂的量控制。然后通过其剩余的醛单元与一系列单酰基酰肼或烷氧基胺的反应来装饰所得的单聚合物链纳米颗粒。或者，线性聚合物链可以通过其醛单元与单酰基酰肼的反应完全装饰，然后通过与双酰肼交联剂的交换反应进行分子内交联。这两种方法被证明是制备具有高功能密度的单链聚合物纳米颗粒的有效途径。
Polymeric nanoparticles were prepared through the chain collapse of linear polymers driven by the formation of dynamic covalent bonds. Linear chains of poly(vinylbenzaldehyde) were intramolecularly cross-linked through the formation of dynamic covalent acylhydrazone bonds with a bis-hydrazide cross-linker. The cross-linking density was shown to be controlled by the amount of crosslinker used. The resulting single polymer chain nanoparticles were then adorned through reaction of their remaining aldehyde units with a series of monoacyl hydrazides or alkoxyamines. Alternatively, the linear polymer chains could be fully adorned by reaction of their aldehyde units with the monoacyl hydrazides and then intramolecularly cross-linked through exchange reactions with the bis-hydrazide cross-linker. Both approaches proved effective routes to prepare single-chain polymer nanoparticles possessing high functional density.